| id |
0731c489-7e83-46af-8eb2-90ca3743ef64 |
| user_id |
8684964a-bab1-4235-93a8-5fd5e24a1d0a |
| job_id |
mheprjok-1199 |
| base_model_name |
xevyo |
| base_model_path |
/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf... |
| model_name |
human lifespan |
| model_desc |
human lifespan and longevity |
| model_path |
/home/sid/tuning/finetune/backend/output/mheprjok- /home/sid/tuning/finetune/backend/output/mheprjok-1199/merged_fp16_hf... |
| source_model_name |
xevyo |
| source_model_path |
/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf... |
| source_job_id |
xevyo-base-v1 |
| dataset_desc |
📌 Study Purpose
The research investigates how m 📌 Study Purpose
The research investigates how much genetics influences human lifespan, and whether the importance of genes increases, decreases, or stays constant with age.
Twin studies are used because comparing identical (MZ) and fraternal (DZ) twins can separate genetic from environmental effects.
🧬 Key Findings (Very Clear Summary)
1️⃣ Genetics explains about 20–30% of lifespan differences
Previous studies showed this, and the current paper confirms it.
2️⃣ Genetic influence is minimal before age 60
Before age 60, MZ and DZ twins show almost no difference in how long they live.
Meaning: environment and random events dominate early-life and mid-life survival.
3️⃣ After age 60, genetic influence becomes strong
After about 60 years:
Identical twins’ lifespans rise and fall together much more strongly than fraternal twins’.
This shows that genes increasingly shape survival at older ages.
Example:
For every extra year an MZ twin lives past 60, the other lives 0.39 extra years.
For DZ twins, this number is only 0.21 years.
4️⃣ Chance of reaching very old age is far more similar in MZ twins
At age 92:
MZ male twins are 4.8× more likely to both reach age 92 than expected by chance.
DZ male twins are only 1.8× more likely.
Female patterns are similar but shifted ~5–10 years later (women live longer).
5️⃣ Genetic effects remain strong even among people who already survived to age 75
In a special group where both twins already lived to 75, MZ twins remain significantly more similar than DZ twins up to age 92.
This confirms:
👉 Genetic influence on longevity does NOT disappear at extreme ages.
🧪 Data Sources
The study uses 20,502 twins from:
Denmark
Sweden
Finland
Born 1870–1910, followed for 90+ years.
This is one of the largest and most complete longevity twin datasets ever collected.
📊 Methods Summary
Two major analysis types:
1. Conditional Lifespan
“How long does one twin live, depending on how long the co-twin lived?”
This detects lifespan similarity.
2. Survival to a Given Age
Twin pairs were checked for:
Relative recurrence risk (RRR) → How much more likely a twin reaches age X if the co-twin did?
Tetrachoric correlation → A statistical measure of shared liability for survival.
Both consistently showed stronger resemblance in MZ twins at older ages.
🧭 Interpretation
What the results mean
Before age 60: Mostly accidents, lifestyle, environment → genetic influence weak.
After age 60: Survival depends more on biology—aging pathways, resistance to diseases, cell repair, etc.
Supports two big ideas:
Genetic influence increases with age for surviving to old ages.
Late-life survival is influenced by:
“Longevity enabling genes”
Genes reducing disease risks
Genes protecting overall health at old ages
🧩 Why It Matters
This study provides scientific justification for ongoing searches for:
Longevity genes
Aging pathway genes
Genetic biomarkers of healthy aging
It also shows that:
👉 Genetics matters most not for reaching 60… but for reaching 80, 90, or 100+.
🏁 Perfect One-Sentence Summary
Genetic influence on human lifespan is small before age 60 but becomes increasingly strong afterward, making genes a major factor in reaching very old ages.... |
| dataset_meta |
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| dataset_path |
/home/sid/tuning/finetune/backend/output/mheprjok- /home/sid/tuning/finetune/backend/output/mheprjok-1199/data/mheprjok-1199.json... |
| training_output |
null |
| status |
completed |
| created_at |
1764883283 |
| updated_at |
1764887996 |
| source_adapter_path |
NULL |
| adapter_path |
/home/sid/tuning/finetune/backend/output/mheprjok- /home/sid/tuning/finetune/backend/output/mheprjok-1199/adapter... |
| plugged_in |
False |