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21850d41-115a-4e3f-ab46-dddedd85f109 |
| user_id |
8684964a-bab1-4235-93a8-5fd5e24a1d0a |
| job_id |
wpbbjtck-1794 |
| base_model_name |
xevyo |
| base_model_path |
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| model_name |
Genetic Determinants |
| model_desc |
Genetic Determinants of Human Longevity |
| model_path |
/home/sid/tuning/finetune/backend/output/wpbbjtck- /home/sid/tuning/finetune/backend/output/wpbbjtck-1794/merged_fp16_hf... |
| source_model_name |
xevyo |
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| source_job_id |
xevyo-base-v1 |
| dataset_desc |
Thestudyof APOE anditsisoformshasspreadinallthestu Thestudyof APOE anditsisoformshasspreadinallthestudiesaboutthegeneticsofhuman longevityandthisisoneofthefirstgenesthatemergedincandidate-genestudiesandingenome-wide analysisindifferenthumanpopulations.Thepleiotropicrolesofthisgeneaswellasthepatternof variabilityacrossdifferenthumangroupsprovideaninterestingperspectiveontheanalysisofthe evolutionaryrelationshipbetweenhumangenetics,environmentalvariables,andtheattainmentof extremelongevityasahealthyphenotype.Inthepresentreview,thefollowingtopicswillbediscussed
Serena Dato obtained a Ph.D. in Molecular Bio-Pathology in 2004. Since September 2006, she has been an Assistant Professor in Genetics at the Department of Cell Biology of the University of Calabria, where she carries out research at the Genetics Laboratory. From the beginnning, her research interests have focused on the study of human longevity and in particular on the development of experimental designs and new analytical approaches for the study of the genetic component of longevity. With her group, she developed an algorithm for integrating demographic data into genetics, which enabled the application of a genetic-demographic analysis to crosssectional samples. She was involved in several recruitment campaigns for the collection of data and DNA samples from old and oldest-old people in her region, both nonagenarian and centenarian families. She has several international collaborations with groups involved in her research field in Europe and the USA. Since 2008, she has been actively collaborating with the research group of Prof. K. Christensen at the Aging Research Center of the Institute of Epidemiology of Southern Denmark University, where she spent a year as a visiting researcher in 2008. Up to now, her work has led to forty-eight scientific papers in peer reviewed journals, two book chapters and presentations at scientific conferences.
Mette Sørensen has been active within ageing research since 2006, with work ranging from functional molecular biological studies to genetic epidemiology and bioinformatics. She obtained a Ph.D. in genetic epidemiology of human longevity in 2012 and was appointed Associate Professor at the University of Southern Denmark in March 2019. Her main research interest is in the mechanisms of ageing, age-related diseases and longevity, with an emphasis on genetic and epigenetic variation. Her work is characterized by a high degree of international collaboration and interdisciplinarity. The work has, per September 2019, led to thirty-one scientific papers in peer reviewed journal, as well as popular science communications, presentations at scientific conferences, media appearances, and an independent postdoctoral grant from the Danish Research Council in 2013.
Giuseppina Rose is Associate Professor in Genetics at the University of Calabria. She graduated from the University of Calabria School of Natural Science in 1983 and served as a Research Assistant there from 1992–1999. In 1994 she achieved a Ph.D. in Biochemistry and Molecular Biology at
Contents
... |
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/home/sid/tuning/finetune/backend/output/wpbbjtck- /home/sid/tuning/finetune/backend/output/wpbbjtck-1794/data/wpbbjtck-1794.json... |
| training_output |
null |
| status |
completed |
| created_at |
1764896439 |
| updated_at |
1764920511 |
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NULL |
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| plugged_in |
False |