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8684964a-bab1-4235-93a8-5fd5e24a1d0a |
| job_id |
ekbckppy-6402 |
| base_model_name |
xevyo |
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| model_name |
breast cancer |
| model_desc |
breast cancer |
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xevyo |
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| dataset_desc |
Key Points
Breast cancer is a group of diseases Key Points
Breast cancer is a group of diseases with different molecular subtypes
Most tumors arise from ductal or lobular epithelium
Most common life-threatening cancer in women worldwide
Often asymptomatic in early stages
Commonly detected by screening mammography
Triple assessment: clinical exam + imaging + biopsy
Easy Explanation
Breast cancer is not a single disease but many types of tumors that start in breast ducts or lobules. Many women have no symptoms at first, which is why screening is very important. Early diagnosis improves survival and allows curative treatment.
Breast Cancer 3
2. Anatomy of the Breast
Key Points
Located on the anterior chest wall
Lies over pectoralis major muscle
Each breast has 15–20 lobes
Lobes contain lobules that produce milk
Supported by ligaments
Fat gives breast its shape and size
Easy Explanation
The breast is made of glands that produce milk, ducts that carry milk, fat for shape, and ligaments for support. Cancer usually starts where cells divide frequently—inside ducts or lobules.
Breast Cancer 3
3. Pathophysiology
Key Points
Cancer develops due to genetic and molecular alterations
Leads to uncontrolled cell growth
Tumors classified by receptor status:
Estrogen receptor (ER)
Progesterone receptor (PR)
HER2 receptor
Breast cancer behaves as distinct diseases, not one entity
Easy Explanation
Normal breast cells become cancerous after DNA damage causes them to grow uncontrollably. The presence or absence of hormone and HER2 receptors determines tumor behavior and treatment.
Breast Cancer 3
4. Molecular Subtypes
Key Points
Luminal A – ER positive, best prognosis
Luminal B – ER positive, more aggressive
HER2-positive – aggressive but treatable
Basal-like / Triple-negative – aggressive, poor prognosis
Easy Explanation
Breast cancers are divided into subtypes based on receptors. These subtypes explain why some cancers grow slowly while others spread rapidly and require stronger treatment.
Breast Cancer 3
5. Histological Types
Key Points
Invasive ductal carcinoma (75–85%)
Invasive lobular carcinoma (<15%)
Medullary carcinoma (~5%)
Mucinous carcinoma (<5%)
Tubular carcinoma (1–2%)
Papillary carcinoma (1–2%)
Metaplastic carcinoma (<1%)
Easy Explanation
Under the microscope, breast cancers look different. Some types grow slowly and have good outcomes, while others are aggressive and spread early.
Breast Cancer 3
6. Etiology / Risk Factors
Key Points
Female gender
Increasing age
Family history of breast or ovarian cancer
BRCA1 / BRCA2 mutations
Early menarche, late menopause
Late first pregnancy or no pregnancy
Hormone replacement therapy
Obesity and alcohol
Radiation exposure
Easy Explanation
Breast cancer risk increases with prolonged hormone exposure, genetic mutations, and certain lifestyle factors. Some risks are modifiable, others are not.
Breast Cancer 3
7. Family History & Genetics
Key Points
Risk increases 4–5 times with first-degree relatives
Male breast cancer suggests genetic mutation
BRCA mutations strongly linked
Genetic risk assessment tools available
Easy Explanation
Women with close relatives affected by breast or ovarian cancer are at higher risk. Genetic testing helps identify those who need close monitoring or preventive strategies.
Breast Cancer 3
8. Reproductive & Hormonal Factors
Key Points
Early menarche
Late menopause
Nulliparity
Late age at first pregnancy
Oral contraceptives (temporary risk increase)
Hormone replacement therapy (especially combined)
Easy Explanation
Longer exposure to estrogen increases the chance of breast cancer. Hormonal medications can influence risk depending on duration and type used.
Breast Cancer 3
9. Lifestyle & Environmental Factors
Key Points
Obesity (especially postmenopausal)
Sedentary lifestyle
Alcohol consumption
Western diet
Radiation exposure (especially during adolescence)
Easy Explanation
Lifestyle plays a major role in breast cancer risk. Healthy diet, exercise, and avoiding unnecessary radiation can reduce risk.
Breast Cancer 3
10. Epidemiology
Key Points
Most common cancer in women globally
Incidence higher in developed countries
Mortality decreasing due to screening and treatment
Median age at diagnosis: 63 years
Easy Explanation
Breast cancer is common worldwide. Better screening and modern treatment have reduced deaths, especially in countries with good healthcare systems.
Breast Cancer 3
11. Clinical Features
Key Points
Often asymptomatic early
Painless breast lump
Skin dimpling or thickening
Nipple inversion or discharge
Enlarged axillary lymph nodes
Easy Explanation
Early breast cancer may cause no symptoms. Any new breast change should be investigated immediately.
Breast Cancer 3
12. Diagnosis
Key Points
Clinical examination
Mammography
Ultrasound
MRI (high-risk cases)
Needle biopsy (confirmation)
Easy Explanation
Imaging detects suspicious lesions, but biopsy is required to confirm cancer and determine its type.
Breast Cancer 3
13. Prognostic Factors
Key Points
Tumor size
Lymph node involvement
Histologic grade
ER / PR status
HER2 status
Response to therapy
Easy Explanation
Certain tumor features help predict survival and guide treatment decisions. Node-negative and hormone-positive cancers have better outcomes.
Breast Cancer 3
14. Prognosis
Key Points
Survival improving over decades
Early-stage cancers have high survival
HER2 prognosis improved with targeted therapy
Triple-negative cancers have poorer outcomes
Easy Explanation
Outcome depends on cancer stage and subtype. Advances in targeted therapy have significantly improved survival.
Breast Cancer 3
15. Associated Conditions
Key Points
Increased cardiovascular disease risk
Treatment-related cardiotoxicity
Long-term follow-up required
Easy Explanation
Breast cancer survivors may develop heart problems due to treatment, making long-term monitoring essential.
Breast Cancer 3
✅ This format is suitable for
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Easy revision notes
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