| id |
ab1de8f5-2a6d-4a82-8de0-cb9e8eadbfce |
| user_id |
8684964a-bab1-4235-93a8-5fd5e24a1d0a |
| job_id |
tjeolvsk-8304 |
| base_model_name |
xevyo |
| base_model_path |
/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf... |
| model_name |
Healthy lifestyle in late |
| model_desc |
Healthy lifestyle in late-life, longevity genes |
| model_path |
/home/sid/tuning/finetune/backend/output/tjeolvsk- /home/sid/tuning/finetune/backend/output/tjeolvsk-8304/merged_fp16_hf... |
| source_model_name |
xevyo |
| source_model_path |
/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf... |
| source_job_id |
xevyo-base-v1 |
| dataset_desc |
This landmark 20-year, nationwide cohort study fro This landmark 20-year, nationwide cohort study from China shows that a healthy lifestyle— even when adopted late in life—substantially lowers mortality risk and increases life expectancy, regardless of one’s genetic predisposition for longevity.
Using data from 36,164 adults aged 65 and older, with genetic analyses on 9,633 participants, the study builds a weighted healthy lifestyle score based on four modifiable factors:
Non-smoking
Non-harmful alcohol intake
Regular physical activity
Healthy, protein-rich diet
Participants were grouped into unhealthy, intermediate, and healthy lifestyle categories. An additional genetic risk score, constructed from 11 lifespan-related SNPs, categorized individuals into low or high genetic risk for shorter lifespan.
Key Findings
A healthy late-life lifestyle reduced all-cause mortality by 44% compared with an unhealthy lifestyle (HR 0.56).
Those with high genetic risk + unhealthy lifestyle had the highest mortality (HR 1.80).
Critically, healthy habits benefited even genetically vulnerable individuals, showing no biological barrier to lifestyle-driven improvement.
At age 65, adopting a healthy lifestyle resulted in 3.8 extra years of life for low-genetic-risk individuals and 4.35 extra years for high-genetic-risk individuals.
Physical activity emerged as the strongest protective behavior.
Benefits persisted even in the oldest-old (age 80–100+), highlighting that lifestyle change is effective at any age.
Significance
The study provides some of the clearest evidence to date that:
Genetics are not destiny: Healthy habits can offset elevated genetic mortality risk.
Even individuals in their 70s, 80s, 90s, and beyond can meaningfully extend their lifespan through lifestyle modification.
Public health and primary care programs should emphasize physical activity, smoking cessation, moderate drinking, and improved diet, especially among older adults with higher genetic susceptibility.
Conclusion
This research powerfully establishes that late-life lifestyle choices are among the most impactful determinants of longevity, surpassing genetic risk and offering significant, measurable extensions in lifespan for older adults.... |
| dataset_meta |
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| dataset_path |
/home/sid/tuning/finetune/backend/output/tjeolvsk- /home/sid/tuning/finetune/backend/output/tjeolvsk-8304/data/tjeolvsk-8304.json... |
| training_output |
null |
| status |
completed |
| created_at |
1764883184 |
| updated_at |
1764888204 |
| source_adapter_path |
NULL |
| adapter_path |
/home/sid/tuning/finetune/backend/output/tjeolvsk- /home/sid/tuning/finetune/backend/output/tjeolvsk-8304/adapter... |
| plugged_in |
False |