| id |
c849e927-e000-4f63-a601-d7b6e2ef75cd |
| user_id |
8684964a-bab1-4235-93a8-5fd5e24a1d0a |
| job_id |
evvycfst-1808 |
| base_model_name |
xevyo |
| base_model_path |
/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf... |
| model_name |
Dublin Longevity |
| model_desc |
Dublin Longevity Declaration |
| model_path |
/home/sid/tuning/finetune/backend/output/evvycfst- /home/sid/tuning/finetune/backend/output/evvycfst-1808/merged_fp16_hf... |
| source_model_name |
xevyo |
| source_model_path |
/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf... |
| source_job_id |
xevyo-base-v1 |
| dataset_desc |
Consensus Recommendation to Immediately Expand Res Consensus Recommendation to Immediately Expand Research on Extending Healthy Human Lifespans
For millennia, the consensus of the general public has been that aging is inevitable. For most of our history, even getting to old age was a significant accomplishment – and while centenarians have been around at least since the time of the Greeks, aging was never of major interest to medicine.
That has changed. Longevity medicine has entered the mainstream. First, evidence accumulated that lifestyle modifications prevent chronic diseases of aging and extend healthspan, the healthy and highly functional period of life. More recently, longevity research has made great progress – aging has been found to be malleable and hundreds of interventional strategies have been identified that extend lifespan and healthspan in animal models. Human clinical studies are underway, and already early results suggest that the biological age of an individual is modifiable.
A concerted effort has been made in the longevity field to institutionalize the word “healthspan”. Why healthspan (how long we stay healthy) and not its side-effect of lifespan (how long we live)? The reasons are linked more to perception than reality. Fundamental to this need to highlight healthspan is the idea that individuals get when they are asked if they want to live longer. Many imagine their parents or grandparents at the end of their lives when they often have major health issues and low quality of life. Then they conclude that they would not choose to live longer in that condition. This is counter to longevity research findings, which show that it is possible to intervene in late middle life and extend both healthspan and lifespan simultaneously. Emphasizing healthspan also reduces concerns of some individuals about whether it is ethical to live longer.
A drawback of this exists, though: many current longevity interventions may extend healthspan more than lifespan. Lifestyle interventions such as exercise probably fit this mold. Many interventions that have dramatic health-extending effects in invertebrate models have more modest effects in mice, and there is a concern that they will be further reduced in humans. In other words, the drugs and small molecules that we are excited about today may, despite their hefty development costs and lengthy approval processes, only extend average healthspan by five or ten years and may not extend maximum lifespan at all. Make no mistake, this would still represent a revolution in medical practice! A five-year extension in human healthspan, with equitable access for all people, would save trillions per year in healthcare costs, provide extra life quality across the entire population ... |
| dataset_meta |
{"input_type": "file", "source {"input_type": "file", "source": "/home/sid/tuning/finetune/backend/output/evvycfst-1808/data/document.pdf"}... |
| dataset_path |
/home/sid/tuning/finetune/backend/output/evvycfst- /home/sid/tuning/finetune/backend/output/evvycfst-1808/data/evvycfst-1808.json... |
| training_output |
null |
| status |
failed |
| created_at |
1764899560 |
| updated_at |
1764900764 |
| source_adapter_path |
NULL |
| adapter_path |
/home/sid/tuning/finetune/backend/output/evvycfst- /home/sid/tuning/finetune/backend/output/evvycfst-1808/adapter... |
| plugged_in |
False |