| id |
e79ebb98-ee16-4b4e-bad1-f67528a16b3c |
| user_id |
8684964a-bab1-4235-93a8-5fd5e24a1d0a |
| job_id |
jzoubfzk-5182 |
| base_model_name |
xevyo |
| base_model_path |
/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf... |
| model_name |
Superior proteome |
| model_desc |
Superior proteome stability in the longest lived |
| model_path |
/home/sid/tuning/finetune/backend/output/jzoubfzk- /home/sid/tuning/finetune/backend/output/jzoubfzk-5182/merged_fp16_hf... |
| source_model_name |
xevyo |
| source_model_path |
/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf... |
| source_job_id |
xevyo-base-v1 |
| dataset_desc |
Superior proteome stability in the longest-lived a Superior proteome stability in the longest-lived animal” investigates why the ocean quahog (Arctica islandica)—a clam that can live over 500 years, the longest-lived animal known—ages extraordinarily slowly. The study reveals that its exceptional lifespan is strongly linked to remarkable stability of its proteome (the full set of proteins in its cells).
The paper explains that aging in most organisms is driven by the gradual accumulation of damaged, misfolded, or aggregated proteins, which disrupt cellular function. Arctica islandica, however, shows:
Key Findings
Extremely low levels of protein oxidation even in very old individuals
Highly efficient protein repair and recycling mechanisms
Exceptional resistance to stress, including oxidative and metabolic stress
Slower protein turnover, meaning proteins remain functional longer without degradation
Stable cellular environment that prevents the buildup of toxic protein aggregates
Together, these mechanisms preserve protein quality for centuries, protecting cells from age-related decline.
Implications
The study suggests that proteome stability is a core determinant of maximum lifespan in animals. It also offers insight into how improving protein maintenance systems in humans could potentially reduce age-related diseases such as neurodegeneration, cardiovascular decline, and metabolic dysfunction.
In essence, Arctica Islandica’s longevity is not a mystery of size or environment—it is a triumph of biochemical housekeeping, where proteins stay “young” far longer than in any other species studied.... |
| dataset_meta |
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| dataset_path |
/home/sid/tuning/finetune/backend/output/jzoubfzk- /home/sid/tuning/finetune/backend/output/jzoubfzk-5182/data/jzoubfzk-5182.json... |
| training_output |
null |
| status |
completed |
| created_at |
1764867070 |
| updated_at |
1764867287 |
| source_adapter_path |
NULL |
| adapter_path |
/home/sid/tuning/finetune/backend/output/jzoubfzk- /home/sid/tuning/finetune/backend/output/jzoubfzk-5182/adapter... |
| plugged_in |
False |