| id |
f79e649f-eda8-48e0-9d2a-2c56d701f647 |
| user_id |
8684964a-bab1-4235-93a8-5fd5e24a1d0a |
| job_id |
ynjzdyfn-6686 |
| base_model_name |
xevyo |
| base_model_path |
/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf... |
| model_name |
Gut microbiota variations |
| model_desc |
Gut microbiota variations over the lifespan and
|
| model_path |
/home/sid/tuning/finetune/backend/output/ynjzdyfn- /home/sid/tuning/finetune/backend/output/ynjzdyfn-6686/merged_fp16_hf... |
| source_model_name |
xevyo |
| source_model_path |
/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf... |
| source_job_id |
xevyo-base-v1 |
| dataset_desc |
This study investigates how the gut microbiota (th This study investigates how the gut microbiota (the community of microorganisms living in the gut) changes throughout the reproductive lifespan of female rabbits and how these changes relate to longevity. It compares two maternal rabbit lines:
Line A – a standard commercial line selected mainly for production traits.
Line LP – a long-lived line created using longevity-based selection criteria.
🔬 What the Study Did
Researchers analyzed 319 fecal samples collected from 164 female rabbits across their reproductive lives (from first parity to death/culling). They used advanced DNA sequencing of the gut microbiome, including:
16S rRNA sequencing
Bioinformatics (DADA2, QIIME2)
Alpha diversity (richness/evenness within a sample)
Beta diversity (differences between samples)
Zero-inflated negative binomial mixed models (ZINBMM)
Animals were categorized into three longevity groups:
LL: Low longevity (died/culled before 5th parity)
ML: Medium longevity (5–10 parities)
HL: High longevity (more than 10 parities)
🧬 Key Findings
1. Aging Strongly Alters the Gut Microbiome
Age caused a consistent decline in diversity:
Lower richness
Lower evenness
Reduced Shannon index
20% of ASVs in line A and 16% in line LP were significantly associated with age.
Most age-associated taxa declined with age.
Age explained the greatest proportion of sample-to-sample microbiome variation.
2. Longevity Groups Have Distinct Microbiomes
High-longevity rabbits (HL) showed lower evenness, meaning fewer taxa dominated the community.
Differences between longevity groups were more pronounced in line A than line LP.
In line A, 15–16% of ASVs differed between HL and LL/ML.
In line LP, only 4% differed.
Suggests genetic selection for longevity stabilizes microbiome patterns.
3. Strong Genetic Line Effects
LP rabbits consistently had higher alpha diversity than A rabbits.
About 6–12% of ASVs differed between lines even when comparing animals of the same longevity, proving:
Genetics shape the microbiome independently of lifespan.
Several bacterial families were consistently different between lines, such as:
Lachnospiraceae
Oscillospiraceae
Ruminococcaceae
Akkermansiaceae
🧩 What It Means
The gut microbiota shifts dramatically with age, even under identical feeding and environmental conditions.
Specific bacteria decline as rabbits age, likely tied to immune changes, reproductive stress, or physiological aging.
Longevity is partially linked to microbiome composition—but genetics strongly determines how much the microbiome changes.
The LP line shows more microbiome stability, hinting at genetic resilience.
🌱 Why It Matters
This research helps:
Understand aging biology in mammals
Identify microbial markers of longevity
Improve breeding strategies for long-lived, healthy livestock
Explore microbiome-driven approaches for health and productivity... |
| dataset_meta |
{"input_type": "file", "source {"input_type": "file", "source": "/home/sid/tuning/finetune/backend/output/ynjzdyfn-6686/data/document.pdf", "num_examples": 47, "bad_lines": 0}... |
| dataset_path |
/home/sid/tuning/finetune/backend/output/ynjzdyfn- /home/sid/tuning/finetune/backend/output/ynjzdyfn-6686/data/ynjzdyfn-6686.json... |
| training_output |
null |
| status |
completed |
| created_at |
1764894867 |
| updated_at |
1764900849 |
| source_adapter_path |
NULL |
| adapter_path |
/home/sid/tuning/finetune/backend/output/ynjzdyfn- /home/sid/tuning/finetune/backend/output/ynjzdyfn-6686/adapter... |
| plugged_in |
False |