| id |
fc6c40ff-0d59-41ff-9a6b-8bb701f3cb97 |
| user_id |
8684964a-bab1-4235-93a8-5fd5e24a1d0a |
| job_id |
tfpnpxjj-2464 |
| base_model_name |
xevyo |
| base_model_path |
/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf... |
| model_name |
Is Extreme Longevity |
| model_desc |
Is Extreme Longevity Associated ... |
| model_path |
/home/sid/tuning/finetune/backend/output/tfpnpxjj- /home/sid/tuning/finetune/backend/output/tfpnpxjj-2464/merged_fp16_hf... |
| source_model_name |
xevyo |
| source_model_path |
/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf... |
| source_job_id |
xevyo-base-v1 |
| dataset_desc |
This study investigates whether extreme longevity This study investigates whether extreme longevity in animals is linked to a broad, multi-stress resistance phenotype, focusing on the ocean quahog (Arctica islandica)—the longest-lived non-colonial animal known, capable of surpassing 500 years of life.
The researchers exposed three bivalve species with dramatically different lifespans to nine types of cellular stress, including mitochondrial oxidative stress and genotoxic DNA damage:
Arctica islandica (≈500+ years lifespan)
Mercenaria mercenaria (≈100+ years lifespan)
Argopecten irradians (≈2 years lifespan)
🔬 Core Findings
Short-lived species are highly stress-sensitive.
The 2-year scallop consistently showed the fastest mortality under all stressors.
Longest-lived species show broadly enhanced stress resistance.
Arctica islandica displayed the strongest resistance to:
Paraquat and rotenone (mitochondrial oxidative stress)
DNA methylating and alkylating agents (nitrogen mustard, MMS)
Long-lived species differ in their stress defense profiles.
Mercenaria (≈100 years) was more resistant to:
DNA cross-linkers (cisplatin, mitomycin C)
Topoisomerase inhibitors (etoposide, epirubicin)
This shows that no single species is resistant to all stressors, even among long-lived clams.
Evidence partially supports the “multiplex stress resistance” model.
While longevity correlates with greater resistance to many stressors, the pattern is not uniform, suggesting different species evolve different protective strategies.
🧠 Biological Significance
Findings support a major idea from comparative aging research:
Long-lived species tend to exhibit superior resistance to cellular damage, especially oxidative and genotoxic stress.
Enhanced DNA repair, durable proteins, low metabolic rates, and strong apoptotic control may contribute to extreme lifespan.
Arctica islandica’s biology aligns with negligible senescence—minimal oxidative damage accumulation and high cellular stability.
📌 Conclusion
Extreme longevity in bivalves is strongly associated with heightened resistance to multiple stressors, but not in a uniform way. Long-lived species have evolved different combinations of cellular defense mechanisms, helping them maintain tissue integrity for centuries.
This study establishes bivalves as powerful comparative models in gerontology and reinforces the concept that resistance to diverse forms of cellular stress is a critical foundation of exceptional longevity.... |
| dataset_meta |
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| dataset_path |
/home/sid/tuning/finetune/backend/output/tfpnpxjj- /home/sid/tuning/finetune/backend/output/tfpnpxjj-2464/data/tfpnpxjj-2464.json... |
| training_output |
null |
| status |
completed |
| created_at |
1764887634 |
| updated_at |
1764892445 |
| source_adapter_path |
NULL |
| adapter_path |
/home/sid/tuning/finetune/backend/output/tfpnpxjj- /home/sid/tuning/finetune/backend/output/tfpnpxjj-2464/adapter... |
| plugged_in |
False |