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a899b0b5-d187-4a93-8cea-938ff817f30a
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8684964a-bab1-4235-93a8-5fd5e24a1d0a
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vmsdiqjm-7013
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xevyo
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/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf...
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Effects of desiccation
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Effects of desiccation stress
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This study presents a systematic review and pooled This study presents a systematic review and pooled survival analysis quantifying the effects of desiccation stress (humidity) and temperature on the adult female longevity of Aedes aegypti and Aedes albopictus, the primary mosquito vectors of arboviral diseases such as dengue, Zika, chikungunya, and yellow fever. The research addresses a critical gap in vector ecology and epidemiology by providing a comprehensive, quantitative model of how humidity influences adult mosquito survival, alongside temperature effects, to improve understanding of transmission dynamics and enhance predictive models of disease risk.
Background
Aedes aegypti and Ae. albopictus are globally invasive mosquito species that transmit several major arboviruses.
Adult female mosquito longevity strongly impacts transmission dynamics because mosquitoes must survive the extrinsic incubation period (EIP) to become infectious.
While temperature effects on mosquito survival have been widely studied and incorporated into models, the role of humidity remains poorly quantified despite being ecologically significant.
Humidity influences mosquito survival via desiccation stress, affecting water loss and physiological function.
Environmental moisture also indirectly affects mosquito populations by altering evaporation rates in larval habitats, impacting larval development and adult body size, which affects vectorial capacity.
Understanding the temperature-dependent and non-linear effects of humidity can improve ecological and epidemiological models, especially in arid, semi-arid, and seasonally dry regions, which are understudied.
Objectives
Systematically review experimental studies on temperature, humidity, and adult female survival in Ae. aegypti and Ae. albopictus.
Quantify the relationship between humidity and adult survival while accounting for temperature’s modifying effect.
Provide improved parameterization for models of mosquito populations and arboviral transmission.
Methods
Systematic Literature Search: 1517 unique articles screened; 17 studies (16 laboratory, 1 semi-field) met inclusion criteria, comprising 192 survival experiments with ~15,547 adult females (8749 Ae. aegypti, 6798 Ae. albopictus).
Inclusion Criteria: Studies must report survival data for adult females under at least two temperature-humidity regimens, with sufficient methodological detail on nutrition and hydration.
Data Extraction: Variables included species, survival times, mean temperature, relative humidity (RH), and provisioning of water, sugar, and blood meals. Saturation vapor pressure deficit (SVPD) was calculated from temperature and RH to represent desiccation stress.
Survival Time Simulation: To harmonize disparate survival data formats (survival curves, mean/median longevity, survival proportions), individual mosquito survival times were simulated via Weibull and log-logistic models.
Pooled Survival Analysis: Stratified and mixed-effects Cox proportional hazards regression models were used to estimate hazard ratios (mortality risks) associated with temperature, SVPD, and nutritional factors.
Model Selection: SVPD was found to fit survival data better than RH or vapor pressure.
Sensitivity Analyses: Included testing model robustness by excluding individual studies and comparing results using only Weibull simulations.
Key Quantitative Findings
Parameter Ae. aegypti Ae. albopictus Notes
Temperature optimum (lowest mortality hazard) ~27.5 °C ~21.5 °C Ae. aegypti optimum higher than Ae. albopictus
Mortality risk trend Increases non-linearly away from optimum; sharp rise at higher temps Similar trend; possibly slightly better survival at lower temps Mortality rises rapidly at high temps for both species
Effect of desiccation (SVPD) Mortality hazard rises steeply from 0 to ~1 kPa SVPD, then more gradually Mortality hazard increases with SVPD but with less clear pattern Non-linear and temperature-dependent relationship
Species comparison (stratified model) Generally lower mortality risk than Ae. albopictus across most conditions Higher mortality risk compared to Ae. aegypti Differences not significant in mixed-effects model
Nutritional provisioning effects Provision of water, sugar, blood meals significantly reduces mortality risk Same as Ae. aegypti Provisioning modeled as binary present/absent
Qualitative and Contextual Insights
Humidity is a significant and temperature-dependent factor affecting adult female survival in Ae. aegypti, with more limited but suggestive evidence for Ae. albopictus.
Mortality risk increases sharply with desiccation stress (SVPD), especially at higher temperatures.
Ae. aegypti tends to have higher survival and a higher thermal optimum than Ae. albopictus, aligning with their geographic distributions—Ae. aegypti favors warmer, drier climates while Ae. albopictus tolerates cooler temperatures.
Provisioning of water and nutrients (sugar, blood) markedly improves survival, reflecting the importance of hydration and energy intake.
The findings support that humidity effects are underrepresented in current mosquito and disease transmission models, which often rely on simplistic or threshold-based mortality assumptions.
The use of SVPD (a measure of desiccation potential) rather than relative humidity or vapor pressure is more appropriate for modeling mosquito survival related to desiccation.
There is substantial unexplained variability among studies, likely due to unmeasured factors such as mosquito genetics, experimental protocols, and microclimatic conditions.
The majority of studies used laboratory settings and tropical/subtropical strains, with very limited data from arid or semi-arid climates, a critical gap given the importance of humidity fluctuations there.
Microclimatic variability and mosquito behavior (e.g., seeking humid refugia) may mitigate desiccation effects in the field, so laboratory results may overestimate mortality under natural conditions.
The study highlights the need for more field-based and arid region studies, and for models to incorporate nonlinear and interactive effects of temperature and humidity on mosquito survival.
Timeline Table: Study Selection and Analysis Process
Step Description
Literature search (Feb 2016) 1517 unique articles screened
Full text review 378 articles assessed for eligibility
Final inclusion 17 studies selected (16 lab, 1 semi-field)
Data extraction Survival data, temperature, humidity, nutrition, species, setting
Survival time simulation Weibull and log-logistic models used to harmonize survival data
Pooled survival analysis Stratified and mixed-effects Cox regression models
Sensitivity analyses Exclusion of individual studies, Weibull-only simulations
Model selection SVPD chosen as best humidity metric
Definitions and Key Terms
Term Definition
Aedes aegypti Primary mosquito vector of dengue, Zika, chikungunya, and yellow fever viruses
Aedes albopictus Secondary vector species with broader climatic tolerance, also transmits arboviruses
Saturation Vapor Pressure Deficit (SVPD) Difference between actual vapor pressure and saturation vapor pressure; a measure of drying potential/desiccation stress
Extrinsic Incubation Period (EIP) Time required for a virus to develop within the mosquito before it can be transmitted
Desiccation stress Physiological stress from water loss due to low humidity, impacting mosquito survival
Stratified Cox regression Survival analysis method allowing baseline hazards to vary by study
Mixed-effects Cox regression Survival analysis
Smart Summary
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6091bea7-3a23-4d1c-8647-5f933aff91ac
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8684964a-bab1-4235-93a8-5fd5e24a1d0a
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qrlwojjn-3033
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xevyo
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/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf...
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Effect of supplemented
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Effect of supplemented water on fecundity
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The study “Effect of Supplemented Water on Fecundi The study “Effect of Supplemented Water on Fecundity and Longevity” examines how different types of water—particularly fruit-infused or nutrient-enriched water—affect the reproductive output (fecundity) and overall lifespan (longevity) of a test organism. The experiment compares the impact of control water versus various supplemented waters such as apple water, showing how hydration quality can influence biological performance.
The findings demonstrate that apple-supplemented water produced the highest fecundity, meaning it led to the greatest number of eggs or offspring compared with all other treatments. This suggests that certain nutrients present in fruit-based water may stimulate reproductive capacity. However, results for longevity were mixed and highly variable, with some supplemented waters increasing lifespan and others having minimal or inconsistent effects. The study highlights the complexity of how hydration quality influences biological processes, emphasizing that while enriched water can boost reproduction, its effects on longevity are not uniform.
Overall, the research concludes that supplemented water can significantly enhance fecundity, but its impact on lifespan depends on the type of supplement and biological conditions, suggesting important implications for nutritional interventions and life-history strategies.
If you want, I can also provide:
✅ A short summary
✅ A 3–4 line description
✅ A student-friendly simple explanation
✅ Quiz questions from this file
Just tell me!...
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{"input_type": "file", "source {"input_type": "file", "source": "/home/sid/tuning/finetune/backend/output/qrlwojjn-3033/data/document.pdf", "num_examples": 245, "bad_lines": 0}...
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bd79e6c3-515f-429b-a541-2c97c10d5086
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8684964a-bab1-4235-93a8-5fd5e24a1d0a
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okhjmgem-7490
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xevyo
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/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf...
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Effect of eliminating
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Effect of eliminating chronic diseases
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Summary
This study, published in Revista de Saúde Summary
This study, published in Revista de Saúde Pública (2013), investigates whether the elimination of certain chronic diseases can lead to a compression of morbidity among elderly individuals in São Paulo, Brazil. It uses population-based data from the 2000 SABE (Health, Wellbeing and Ageing) study and official mortality records to evaluate changes in disability-free life expectancy (DFLE) resulting from the hypothetical removal of specific chronic conditions.
Background and Objectives
Chronic non-communicable diseases (NCDs) such as cardiovascular diseases, diabetes, and chronic pulmonary conditions account for approximately 50% of diseases in developing countries and are major contributors to morbidity and mortality.
In Brazil, these diseases represent the main health burden and priority for healthcare systems.
The compression of morbidity theory posits that delaying the onset of debilitating diseases compresses the period of morbidity into a shorter segment at the end of life, thus increasing healthy life expectancy.
Other theories include:
Expansion of morbidity: Mortality declines due to reduced lethality but incidence remains or increases, leading to longer periods of morbidity.
Dynamic equilibrium: Both mortality and morbidity decline, keeping years lived with severe disability relatively constant.
The study aims to analyze whether eliminating certain chronic diseases would compress morbidity among elderly individuals, improving overall health expectancy.
Methodology
Design: Analytical, population-based, cross-sectional study.
Population: 2,143 elderly individuals (aged 60+) from São Paulo, Brazil, sampled probabilistically in 2000 as part of the SABE study.
Data collection:
Structured questionnaire covering sociodemographics, health status, functional capacity, and chronic diseases.
Self-reported presence of 9 chronic diseases based on ICD-10: systemic arterial hypertension, diabetes mellitus, heart disease, lung disease, cancer, joint disease, cerebrovascular disease, falls in previous year, and nervous/psychiatric problems.
Functional disability defined by difficulties in activities of daily living (dressing, eating, bathing, toileting, ambulation, fecal and urinary incontinence).
Statistical analysis:
Sullivan’s method used to compute life expectancy (LE) and disability-free life expectancy (DFLE).
Cause-deleted life tables estimated probabilities of death with elimination of specific diseases.
Multiple logistic regression (controlling for age) assessed disability prevalence changes with disease elimination.
Assumption: independence between causes of death and disability.
Sampling weights and corrections for design effects were applied to represent the São Paulo elderly population.
Key Findings
Sample Characteristics
Females represented 58.6% of the sample.
Higher proportion of women aged 75+ (24.2%) than men (19.2%).
Women more frequently widowed or single; men had higher employment rates.
Women more likely to live alone.
Smart Summary
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187ddbfd-84ab-4571-9e41-099455906034
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8684964a-bab1-4235-93a8-5fd5e24a1d0a
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okwjawrr-5385
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xevyo
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/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf...
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Effect of Nutritional
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Effect of Nutritional Interventions on Longevity
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The study “Effect of Nutritional Interventions on The study “Effect of Nutritional Interventions on Longevity of Senior Cats” investigates whether specific dietary modifications can extend the lifespan and improve the health of aging cats. Aging in cats is associated with oxidative stress, declining organ function, and increased vulnerability to disease, and the study explores whether nutrition can mitigate these effects. It evaluates three diets: a control diet, a diet enriched with antioxidants (vitamin E and β-carotene), and a third diet combining antioxidants with additional prebiotics and omega-6 and omega-3 fatty acids.
The researchers conducted a multi-year trial using healthy mixed-breed cats aged 7–17 years, divided equally among the three diet groups. Health markers, blood values, body composition, and survival were monitored throughout the cats' lives. Results showed that cats fed Diet 3—the diet containing antioxidants, chicory root (prebiotic), and a blend of fatty acids—experienced significant health benefits. These cats maintained better body weight, body condition, lean body mass, bone density, and healthier gut microflora than cats on the other diets. They also had higher levels of serum vitamin E, β-carotene, and linoleic acid.
Most importantly, Diet 3 significantly increased lifespan. Cats on this diet had a 61% lower hazard of death compared with those on the control diet, living on average about one year longer when adjusted for age. They also showed fewer cases of thyroid disease and a trend toward reduced gastrointestinal pathology.
The study concludes that a multi-nutrient dietary strategy—combining antioxidants, prebiotics, and essential fatty acids—can meaningfully improve longevity and overall health in senior cats, offering evidence that targeted nutrition plays a powerful role in healthy aging.
If you want, I can also provide:
✅ A shorter summary
✅ A 1-paragraph description
✅ MCQs/quiz from the file
✅ A simplified student-friendly version
...
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{"input_type": "file", "source {"input_type": "file", "source": "/home/sid/tuning/finetune/backend/output/okwjawrr-5385/data/document.pdf", "num_examples": 298, "bad_lines": 0}...
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ac6b20fd-5c74-4e34-bbf1-42e3985b17e8
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8684964a-bab1-4235-93a8-5fd5e24a1d0a
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skdznffn-5496
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xevyo
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/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf...
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Effect of Exceptional
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Effect of Exceptional Parental Longevity
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Summary
This study investigates the relationship Summary
This study investigates the relationship between exceptional parental longevity and the prevalence of cardiovascular disease (CVD) in their offspring, with a focus on whether lifestyle, socioeconomic status, and dietary factors influence this association. Conducted on a cohort of Ashkenazi Jewish adults aged 65-94, the research compares two groups: offspring of parents with exceptional longevity (OPEL), defined as having at least one parent living beyond 95 years, and offspring of parents with usual survival (OPUS), whose parents did not survive past 95 years. The study finds that OPEL exhibit significantly lower prevalence of hypertension, stroke, and overall cardiovascular disease compared to OPUS, independent of lifestyle, socioeconomic, and nutritional differences, thus highlighting a probable genetic influence on disease-free survival and longevity.
Background and Rationale
Individuals with exceptional longevity often experience a delay or absence of age-related diseases, making them models for studying healthy aging.
Longevity has a heritable component, with genetic markers linked to extended lifespan and resistance to diseases like CVD.
Previous studies have shown that offspring of exceptionally long-lived parents have lower incidence of CVD and other age-related illnesses.
Lifestyle factors such as physical activity, diet, smoking status, and socioeconomic status are known to influence cardiovascular health in the general population.
Prior to this study, no research compared lifestyle factors between offspring of exceptionally long-lived parents and those of usual longevity to isolate genetic effects from environmental factors.
Study Design and Methods
Population: 845 Ashkenazi Jewish adults aged 65-94 years; 395 OPEL and 450 OPUS.
Definition:
OPEL: At least one parent lived past 95 years.
OPUS: Both parents died before 95 years.
Recruitment: Systematic searches via voter registration, synagogues, community groups, and advertisements.
Exclusion Criteria: Baseline dementia, severe sensory impairments, or sibling already enrolled.
Data Collection:
Medical history including hypertension (HTN), diabetes mellitus (DM), myocardial infarction (MI), congestive heart failure (CHF), coronary interventions, and stroke.
Lifestyle factors: smoking history, alcohol use, physical activity level.
Socioeconomic factors: education and social strata score.
Dietary intake assessed in a subgroup (n=234) using the Block Brief Food Frequency Questionnaire (FFQ 2000).
Physical measures: height, weight, waist circumference; BMI calculated.
Analysis:
Comparison of prevalence of diseases and lifestyle variables between OPEL and OPUS.
Statistical adjustments for age, sex, BMI, tobacco use, social strata, and physical activity.
Stratified analyses by cardiovascular risk status (high vs. low).
Interaction testing between group status and lifestyle/socioeconomic factors.
Key Findings
Demographics and Lifestyle Factors
Characteristic OPEL (n=395) OPUS (n=450) p-value
Female (%) 59 50 <0.01
Age (years, mean ± SD) 75 ± 6 76 ± 7 <0.01
Education (years) 17 ± 3 17 ± 3 0.55
Social strata score (median, IQR) 56 (28-66) 56 (28-66) 0.76
Ever smokers (%) 55 54 0.80
Current smokers (%) 3 3 0.94
Alcohol use past year (%) 90 88 0.32
Strenuous physical activity (times/week, median) 3 (0-4) 3 (0-4) 0.71
Walking endurance >30 minutes (%) 77 70 0.05
No significant differences in lifestyle factors (smoking, alcohol, physical activity) or socioeconomic status between OPEL and OPUS.
OPEL reported greater walking endurance despite similar physical activity frequency.
Physical Characteristics and Disease Prevalence
Condition / Measure OPEL OPUS p-value OR (95% CI)a
BMI (mean ± SD) 27.5 ± 4.9 27.8 ± 4.7 0.34 Not specified
Obesity (%) (BMI≥30) 26 27 0.84 Not specified
Abdominal obesity (%) 48 48 0.95 Not specified
Systolic BP (mmHg) 129 ± 17 129 ± 17 0.78 Not specified
Diastolic BP (mmHg) 74 ± 9 74 ± 10 0.92 Not specified
Antihypertensive medication use (%) 39 49 <0.01 Not specified
Hypertension (%) 42 51 <0.01 0.71 (0.53–0.95)
Diabetes mellitus (%) 7 11 0.10 0.70 (0.43–1.15) NS
Myocardial infarction (%) 5 7 0.12 0.77 (0.42–1.42) NS
Stroke (%) 2 5 <0.01 0.35 (0.14–0.88)
Cardiovascular disease (composite) (%) 12 20 <0.01 0.65 (0.43–0.98)
OPEL had significantly lower odds of hypertension, stroke, and overall CVD compared to OPUS after adjusting for age and sex.
No significant differences observed for diabetes, MI, CHF, or coronary interventions after adjustment.
OPUS more frequently used antihypertensive medications despite similar blood pressure readings.
Stratified Cardiovascular Risk Analysis
Among high-risk individuals (defined by diabetes or ≥2 risk factors: obesity, hypertension, smoking), OPEL had a significantly lower prevalence of CVD compared to OPUS (OR 0.45; p=0.01).
Among low-risk individuals, no significant difference in CVD prevalence was observed between groups.
Significant interaction found between group status and tobacco use:
Tobacco use was not significantly associated with increased CVD odds in OPEL.
Tobacco use was nearly significantly associated with increased CVD odds in OPUS (p=0.07).
Dietary Intake (Subgroup, n=234)
Dietary Component OPEL OPUS p-value Adjusted p-valuea
Total daily calories (kcal) 1119 (906–1520) 1218 (940–1553)
Smart Summary
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b0a28646-1043-4648-a0f9-13b684bfac38
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8684964a-bab1-4235-93a8-5fd5e24a1d0a
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hunsxdfl-4743
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xevyo
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/home/sid/tuning/finetune/backend/output/xevyo-bas /home/sid/tuning/finetune/backend/output/xevyo-base-v1/merged_fp16_hf...
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Economic
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Economic development
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Economic growth health and poverty
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{"num_examples": 163, "bad_lines": {"num_examples": 163, "bad_lines": 0}...
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{"train_runtime": 651.4982, "train_sam {"train_runtime": 651.4982, "train_samples_per_second": 2.456, "train_steps_per_second": 0.307, "total_flos": 7555123985276928.0, "train_loss": 0.516647665053606, "epoch": 9.536585365853659, "step": 200}...
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racictsh-8494
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Eating for Health
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Eating for Health and Longevity
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“Eating for Health and Longevity” is a practical, “Eating for Health and Longevity” is a practical, evidence-based guide created by SUNY Downstate Health Sciences University to help individuals improve or even reverse chronic disease through a whole-food, plant-based (WFPB) diet. Designed as an accessible handbook, the document explains why diets rich in unprocessed plant foods—vegetables, fruits, whole grains, legumes, nuts, and seeds—can dramatically enhance long-term health, promote healthy weight, and reduce the risk of conditions such as diabetes, heart disease, obesity, and high blood pressure.
The guide defines a WFPB diet as centered on natural, minimally processed plants while minimizing or eliminating meat, dairy, eggs, refined oils, refined grains, added sugars, and highly processed foods. It distinguishes WFPB eating from veganism by emphasizing nutritional quality rather than simply the absence of animal products.
It offers detailed, beginner-friendly guidance on:
What to eat (whole grains, legumes, vegetables, fruits, nuts, seeds, unsweetened plant milks)
What to avoid (meat, processed foods, refined sugars, oils, dairy, refined grains)
Step-by-step ways to transition gradually without overwhelm
Affordable, nutrient-dense sources of plant protein
Shopping lists and cost-saving strategies
Cooking techniques without oil, including sautéing with water or broth, steaming, roasting with parchment, and air frying
Healthy substitutions for meat, dairy, eggs, oil, and sugar
Motivation, support, and educational resources, including films, books, websites, and community groups
The guide also includes a rich section on herbs and spices that add flavor while providing antioxidant and anti-inflammatory benefits, such as turmeric, rosemary, ginger, basil, garlic, cinnamon, and cumin.
In closing, the document encourages readers to view food as medicine—a central pillar of lifestyle medicine alongside exercise, sleep, stress management, and avoiding harmful substances. It positions WFPB eating as an empowering, sustainable pathway toward vibrant health, chronic disease prevention, and longevity....
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Eating for Health
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Eating for Health and Longevity
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Summary: Eating for Health and Longevity – A Pract Summary: Eating for Health and Longevity – A Practical Guide to Whole-Food, Plant-Based Diets
This guide, produced by SUNY Downstate Health Sciences University, provides a comprehensive, evidence-based overview of adopting a whole-food, plant-based (WFPB) diet to promote health, prevent chronic disease, and improve longevity. It offers practical advice for transitioning to plant-based eating, highlights nutritional benefits, and addresses common concerns and misconceptions.
Core Concepts of a Whole-Food, Plant-Based Diet
Definition: A WFPB diet emphasizes eating whole, minimally processed plant foods such as vegetables, fruits, whole grains, legumes, nuts, and seeds.
Exclusions: It minimizes or avoids meat, poultry, fish/seafood, eggs, dairy, refined carbohydrates (e.g., white bread, white rice), refined sugars, extracted oils, and highly processed foods.
Difference from Vegan Diet: Unlike some vegan diets, which may include refined grains, sweeteners, and oils, the WFPB diet focuses on whole foods for optimal health.
Health Benefits
Chronic Disease Prevention and Reversal: WFPB diets can prevent, manage, and sometimes reverse diseases such as diabetes, heart disease, obesity, and hypertension.
Weight Management: Effective for losing excess weight and maintaining a healthy weight.
Longevity and Vitality: Promotes vibrant health and potentially longer life by reducing lifestyle-related risk factors.
Foods to Include and Avoid
Foods to Eat and Enjoy Foods to Avoid or Minimize
Fresh and frozen vegetables Meats (red, processed, poultry, fish/seafood)
Fresh fruits Refined grains (white rice, white pasta, white bread)
Whole grains (oats, quinoa, barley) Products with refined sugars or sweeteners (sodas, candy)
Legumes (peas, lentils, beans) Highly processed or convenience foods with added salt
Unsalted nuts and seeds Eggs and dairy products
Dried fruits without additives Processed plant-based meat, cheese, or butter alternatives
Unsweetened non-dairy milks Refined, extracted oils (olive oil, canola, vegetable)
Alcoholic beverages
Smart Summary
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EXERCISE FOR LONGEVITY
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EXERCISE FOR LONGEVITY
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The Longevity Exercise Guide is a clear, actionabl The Longevity Exercise Guide is a clear, actionable, science-based blueprint for building an exercise routine that maximizes both healthspan and lifespan. Written by longevity researcher Nina Patrick, PhD, the guide distills the most important forms of physical activity—strength, aerobic, anaerobic, flexibility, stability, and NEAT—into a simple weekly plan anyone can follow. The premise is that exercise is the most powerful “longevity drug” available, with research showing it prevents disease, preserves independence, and protects metabolism and cognitive function as we age.
The guide teaches you how to train your body so that at age 100, you can still perform essential daily tasks—carrying groceries, climbing stairs, hiking, balancing, lifting, and moving confidently through life. It emphasizes consistency, personalization, and a balanced mix of training styles that work together to delay aging at the cellular, metabolic, and functional levels.
🧩 What the Guide Covers
1. Strength Training — The Foundation of Aging Well
Prevents muscle loss, frailty, and poor mobility
Recommended 2–3 full-body sessions/week, 45–60 minutes
Mix of heavy low-rep strength work + lighter high-rep endurance work
Includes weights, resistance bands, and bodyweight movements
Longevity_Exercise_Guide (
Strength is directly tied to independence in old age.
2. Aerobic Exercise — Boosting Metabolism & Mitochondria
Brisk walking, running, swimming, cycling
Key for mitochondrial health, cardiovascular fitness, disease prevention
Target: 3 hours/week (150 minutes minimum)
Low-intensity “zone 2” style cardio at 65–75% max HR
Longevity_Exercise_Guide (
Aerobic training slows metabolic aging and improves energy systems.
3. Anaerobic Exercise — Increasing VO₂ Max
Short, fast, high-intensity intervals (HIIT, hard cycling, rowing)
VO₂ max is the strongest predictor of longevity
Suggested: 1–2 intense sessions per week, 30 minutes each
Longevity_Exercise_Guide (
Maintains peak cardiovascular performance as VO₂ max naturally declines with age.
4. Flexibility & Stability — Protecting Balance and Preventing Falls
Yoga, pilates, planks, stretching
Critical because falls are the #1 cause of injury and death in older adults
Enhances posture, core strength, mobility, and balance
Longevity_Exercise_Guide (
Flexibility + stability ensure you can move safely for life.
5. NEAT — The Most Overlooked Longevity Tool
Non-Exercise Activity Thermogenesis = everything you do outside workouts
(e.g., walking, standing, chores)
Boosts daily calorie burn
Counters modern sedentary lifestyles
Reduces metabolic disease and weight gain
Examples: daily steps, walking for errands, housework, standing more
Longevity_Exercise_Guide (
NEAT is essential because most people fail to move enough outside formal workouts.
🧭 Weekly Longevity Blueprint
The guide provides a sample week integrating all modalities:
Strength: 3 full-body sessions
Aerobic: 3 brisk walks
Anaerobic: 1 HIIT/VO₂ max workout
Flexibility/Stability: daily stretching + 1 yoga/pilates class
NEAT: daily 30-minute walk
Longevity_Exercise_Guide (
This structure covers every dimension of functional longevity.
💡 Why This Guide Matters
The Longevity Exercise Guide reframes exercise not as a fitness task but as a lifelong strategy for independence, vitality, and disease prevention. Rather than prescribing a rigid routine, it teaches how to build a personalized, sustainable program that strengthens the body’s most essential aging-related systems:
muscle strength
cardiovascular endurance
metabolic flexibility
balance and mobility
everyday movement patterns
It’s a practical roadmap for anyone who wants to age not only longer, but better....
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ESSENTIAL STEPS TO HEALTH
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ESSENTIAL STEPS TO HEALTHY AGING
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“Essential Steps to Healthy Aging” is an education “Essential Steps to Healthy Aging” is an educational guide created by Kansas State University to teach people how to age in the healthiest, happiest, and most independent way possible. The document explains that while ageing is natural and unavoidable, our daily habits throughout life have a powerful impact on how well we age. It presents 12 essential lifestyle behaviors that research shows contribute to living longer, staying healthier, and maintaining quality of life into older age.
The file includes a leader’s guide, a fact sheet for participants, an interactive activity, and an evaluation form, making it a complete learning program for communities, workshops, or health-education sessions.
⭐ Core Message of the Document
Healthy aging is not about avoiding age—it’s about supporting the body, mind, and spirit across the entire lifespan.
The guide encourages people to take responsibility for their health and to make small but meaningful changes that promote lifelong well-being.
⭐ The 12 Essential Steps to Healthy Aging
(as presented in the fact sheet)
Essential-Steps-to-Health-Aging
Maintain a positive attitude
Eat healthfully
Engage in regular physical activity
Exercise your brain
Engage in social activity
Practice lifelong learning
Prioritize safety
Visit the doctor regularly
Manage your stress
Practice good financial management
Get enough sleep
Take at least 10 minutes a day for yourself
These steps address all areas of life—physical health, mental sharpness, emotional balance, relationships, safety, finances, and self-care.
⭐ Program Purpose
The guide aims to help people understand that:
Healthier choices today lead to a healthier and more independent future.
Positive habits at any age can improve longevity and quality of life.
Ageing well is possible through prevention, awareness, and small daily behaviors.
⭐ Contents of the Document
✔ 1. Leader’s Guide
Explains how to run the program, prepare materials, engage participants, and guide discussions.
Essential-Steps-to-Health-Aging
✔ 2. Essential Steps to Healthy Aging (Fact Sheet)
A clear, easy-to-read summary of all 12 steps and why they matter.
✔ 3. Activity: My Healthy Aging Plan
Participants write specific goals for each of the 12 steps, helping them create a personalized lifestyle improvement plan.
Essential-Steps-to-Health-Aging
✔ 4. Evaluation Form
Participants reflect on what they learned and choose which positive habits they plan to adopt going forward.
Essential-Steps-to-Health-Aging
⭐ Overall Meaning
The document teaches that healthy aging is achievable for everyone, regardless of age. By focusing on attitude, nutrition, physical health, mental activity, social connections, safety, finances, stress, sleep, and self-care, people can enjoy a longer life with greater independence, better health, and improved well-being.
It is both a practical guide and a motivational toolkit for anyone interested in ageing well....
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ESSENTIAL STEPS TO HEALTH
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ESSENTIAL STEPS TO HEALTHY AGING
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Kansas State University Agricultural Experiment St Kansas State University Agricultural Experiment Station and Cooperative Extension Service
Author: Erin Yelland, Ph.D., Extension Specialist, Adult Development and Aging
Program Overview
The Essential Steps to Healthy Aging is a structured educational program designed to motivate and empower participants to adopt healthy lifestyle behaviors that foster optimal aging. Developed by Kansas State University’s Cooperative Extension Service, this program highlights that aging is inevitable, but how individuals care for themselves physically, mentally, and emotionally throughout life significantly influences the quality of their later years. The program promotes the idea that healthy lifestyle changes can positively impact well-being at any age.
Core Concept
Aging well is a lifelong process influenced by daily choices. Research on centenarians (people aged 100 and over) shows that adopting certain healthy behaviors contributes to longevity and improved quality of life. The program introduces 12 essential steps to maintain health and enhance successful aging.
The 12 Essential Steps to Healthy Aging
Step Number Essential Healthy Behavior
1 Maintain a positive attitude
2 Eat healthfully
3 Engage in regular physical activity
4 Exercise your brain
5 Engage in social activity
6 Practice lifelong learning
Smart Summary
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Dublin Longevity
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Dublin Longevity Declaration
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Consensus Recommendation to Immediately Expand Res Consensus Recommendation to Immediately Expand Research on Extending Healthy Human Lifespans
For millennia, the consensus of the general public has been that aging is inevitable. For most of our history, even getting to old age was a significant accomplishment – and while centenarians have been around at least since the time of the Greeks, aging was never of major interest to medicine.
That has changed. Longevity medicine has entered the mainstream. First, evidence accumulated that lifestyle modifications prevent chronic diseases of aging and extend healthspan, the healthy and highly functional period of life. More recently, longevity research has made great progress – aging has been found to be malleable and hundreds of interventional strategies have been identified that extend lifespan and healthspan in animal models. Human clinical studies are underway, and already early results suggest that the biological age of an individual is modifiable.
A concerted effort has been made in the longevity field to institutionalize the word “healthspan”. Why healthspan (how long we stay healthy) and not its side-effect of lifespan (how long we live)? The reasons are linked more to perception than reality. Fundamental to this need to highlight healthspan is the idea that individuals get when they are asked if they want to live longer. Many imagine their parents or grandparents at the end of their lives when they often have major health issues and low quality of life. Then they conclude that they would not choose to live longer in that condition. This is counter to longevity research findings, which show that it is possible to intervene in late middle life and extend both healthspan and lifespan simultaneously. Emphasizing healthspan also reduces concerns of some individuals about whether it is ethical to live longer.
A drawback of this exists, though: many current longevity interventions may extend healthspan more than lifespan. Lifestyle interventions such as exercise probably fit this mold. Many interventions that have dramatic health-extending effects in invertebrate models have more modest effects in mice, and there is a concern that they will be further reduced in humans. In other words, the drugs and small molecules that we are excited about today may, despite their hefty development costs and lengthy approval processes, only extend average healthspan by five or ten years and may not extend maximum lifespan at all. Make no mistake, this would still represent a revolution in medical practice! A five-year extension in human healthspan, with equitable access for all people, would save trillions per year in healthcare costs, provide extra life quality across the entire population ...
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Drivers of your health
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Drivers of your health and longevity
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“Drivers of Your Health and Longevity” is a compre “Drivers of Your Health and Longevity” is a comprehensive report outlining the 23 key modifiable factors that significantly influence a person’s health, lifespan, and overall well-being. It emphasizes that 19 out of these 23 drivers lie outside the traditional healthcare system, meaning most of what determines longevity comes from everyday habits and environmental conditions.
These drivers are grouped into major categories:
1. Physical Inputs
Covers diet, supplements, substance use, hydration, and their direct effects on disease risk, cognitive health, and mortality. Examples include fasting improving metabolic health, omega-3 protecting the brain and heart, and sleep duration affecting mortality.
2. Movement
Includes mobility and exercise. The report highlights that regular physical activity can extend life by 3–5 years, reduce mortality risk, and improve overall physical and mental function.
3. Daily Living
Encompasses social interaction, productive activities, content consumption, and hygiene. Strong social relationships, volunteering, and balanced media usage are linked to better physical and mental health.
4. Exposure
Focuses on nature, atmospheric conditions, light, noise, and environmental materials. Evidence shows that nature exposure, reduced pollution, sunlight, and safe environments contribute to better mental health, reduced stress, and lower mortality.
5. Stress
Explains how both positive (eustress) and chronic stress affects disease risk, cognitive function, and life expectancy.
6. State of Being
Includes mindsets, beliefs, body composition, physical security, and economic security. Optimism, gratitude, financial stability, and safety are shown to have strong physiological and psychological benefits.
7. Healthcare
Covers vaccination, early detection, treatment, and medication adherence. Effective healthcare interventions (e.g., vaccines, screening, treatments) significantly reduce mortality and improve survival rates.
📌 Overall Purpose of the Report
The document emphasizes that longevity is not determined primarily by genetics or medical care, but by daily choices, behaviors, and environmental exposures. By optimizing these 23 modifiable drivers, individuals can dramatically improve their health span and lifespan.
If you want, I can also provide:
✅ A short summary
✅ A quiz based on this file
✅ Key insights
✅ A table of the 23 drivers
Just tell me!
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Diet-dependent entropic a
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Diet-dependent entropic assessment of athletes’
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Cennet Yildiz1, Melek Ece Öngel2 , Bayram Yilmaz3 Cennet Yildiz1, Melek Ece Öngel2 , Bayram Yilmaz3 and Mustafa Özilgen1* 1Department of Food Engineering, Yeditepe University, Kayısdagi, Atasehir, Istanbul 34755, Turkey 2Nutrition and Dietetics Department, Yeditepe University, Kayısdagi, Atasehir, Istanbul 34755, Turkey 3Faculty of Medicine, Department of Physiology, Yeditepe University, Istanbul, Turkey
(Received 29 July 2021 – Final revision received 26 August 2021 – Accepted 26 August 2021)
Journal of Nutritional Science (2021), vol. 10, e83, page 1 of 8 doi:10.1017/jns.2021.78
Abstract Life expectancies of the athletes depend on the sports they are doing. The entropic age concept, which was found successful in the previous nutrition studies, will be employed to assess the relation between the athletes’ longevity and nutrition. Depending on their caloric needs, diets are designed for each group of athletes based on the most recent guidelines while they are pursuing their careers and for the post-retirement period, and then the metabolic entropy generation was worked out for each group. Their expected lifespans, based on attaining the lifespan entropy limit, were calculated. Thermodynamic assessment appeared to be in agreement with the observations. There may be a significant improvement in the athletes’ longevity if theyshift to a retirement diet after the age of 50. The expected average longevity for male athletes was 56 years for cyclists, 66 years for weightlifters, 75 years for rugby players and 92 years for golfers. If they should start consuming the retirement diet after 50 years of age, the longevity of the cyclists may increase for 7 years, and those of weightlifters, rugby players and golfers may increase for 22, 30 and 8 years, respectively.
Key words: Athletes’ diet: Athletes’ longevity: Entropic age: Lifespan entropy
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Diet in Longevity
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Diet in Longevity
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“Longevity Diet” is a concise, practical guide tha “Longevity Diet” is a concise, practical guide that outlines how specific dietary substitutions and eating patterns can support healthier aging, extend lifespan, and reduce the risk of chronic disease. The document promotes a nutrient-dense, low-inflammation way of eating that emphasizes whole foods, plant-forward choices, and strategic replacements for common staples that accelerate aging.
The guide presents a clear set of food swaps designed to improve metabolic health, reduce oxidative stress, and support a stronger, longer-living body. It recommends replacing refined starches—such as bread, pasta, and white rice—with vegetables, legumes, mushrooms, and whole grains like quinoa. Red and processed meats are minimized in favor of fatty fish (like salmon, mackerel, sardines), white meat, eggs, tofu, or mushrooms. High-fat spreads and dressings are replaced with extra-virgin olive oil and other healthy fats, while processed sugars and excessive salt are swapped for herbs, spices, and “Lite Salt.”
The document encourages replacing cow’s milk with plant-based alternatives such as coconut, hemp, or pea milk. Beverages like soda and commercial fruit juice are substituted with water, tea, herbal teas, or moderate coffee intake. Snacks high in sugar are replaced with fruit, natural sweeteners, or high-cocoa dark chocolate.
It also emphasizes using targeted nutritional supplements—such as B vitamins, iodine, selenium, vitamin D, vitamin K2, and magnesium—to address common micronutrient gaps. Specialized “longevity supplements,” such as those formulated to counteract cellular aging, are listed as complementary options.
The centerpiece of the document is the “10 Simple Rules of the Longevity Diet,” which provide deeper guidance: eat fewer refined starches, limit red meat, hydrate well, favor whole ingredients (30+ per week), maintain moderate protein intake, eat slightly less than full to promote metabolic health, include fermented foods, minimize alcohol, and avoid nutrient deficiencies.
Overall, the Longevity Diet promotes a style of eating that is diverse, minimally processed, rich in phytonutrients and healthy fats, and aligned with scientific insights into metabolic health, the gut microbiome, inflammation, and biological aging....
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Developmental Diet Alters
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Developmental Diet Alters the Fecundity–Longevity
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Drosophila melanogaster David H. Collins, PhD,*, D Drosophila melanogaster David H. Collins, PhD,*, David C. Prince, PhD, Jenny L. Donelan, MSc, Tracey Chapman, PhD , and Andrew F. G. Bourke, PhD School of Biological Sciences, University of East Anglia, Norwich, UK. *Address correspondence to: David H. Collins, PhD. E-mail: David.Collins@uea.ac.uk Decision Editor: Gustavo Duque, MD, PhD (Biological Sciences Section)
Abstract The standard evolutionary theory of aging predicts a negative relationship (trade-off) between fecundity and longevity. However, in principle, the fecundity–longevity relationship can become positive in populations in which individuals have unequal resources. Positive fecundity–longevity relationships also occur in queens of eusocial insects such as ants and bees. Developmental diet is likely to be central to determining trade-offs as it affects key fitness traits, but its exact role remains uncertain. For example, in Drosophila melanogaster, changes in adult diet can affect fecundity, longevity, and gene expression throughout life, but it is unknown how changes in developmental (larval) diet affect fecundity–longevity relationships and gene expression in adults. Using D. melanogaster, we tested the hypothesis that varying developmental diets alters the directionality of fecundity–longevity relationships in adults, and characterized associated gene expression changes. We reared larvae on low (20%), medium (100%), and high (120%) yeast diets, and transferred adult females to a common diet. We measured fecundity and longevity of individual adult females and profiled gene expression changes with age. Adult females raised on different larval diets exhibited fecundity–longevity relationships that varied from significantly positive to significantly negative, despite minimal differences in mean lifetime fertility or longevity. Treatments also differed in age-related gene expression, including for aging-related genes. Hence, the sign of fecundity–longevity relationships in adult insects can be altered and even reversed by changes in larval diet quality. By extension, larval diet differences may represent a key mechanistic factor underpinning positive fecundity–longevity relationships observed in species such as eusocial insects. Keywords: Aging, Eusociality, Life history, mRNA-seq, Nutrition
The standard evolutionary theory of aging predicts that, as individuals grow older, selection for increased survivorship declines with age (1). Therefore, individuals experience the age-related decrease in performance and survivorship that defines aging (senescence) (2). Additionally, given finite resources, individuals should optimize relative investment between reproduction and somatic maintenance (3). This causes tradeoffs between reproduction and longevity (4,5) with elevated reproduction often incurring costs to longevity (the costs of reproduction) (6). Such trade-offs and costs are evident in the negative fecundity–longevity relationships observed in many species. Although a negative fecundity–longevity relationship is typical, fecundity and longevity can become uncoupled (7) and some species or populations may exhibit positive fecundity– longevity relationships (4). This can occur for several reasons. First, in Drosophila melanogaster, mutations can increase longevity without apparent reproductive costs (8–11), particularly mutations in the conserved insulin/insulin-like growth factor signaling and target of rapamycin network (IIS-TOR).
This network regulates nutrient sensitivity and is an important component of aging across diverse taxa (2,12). Second, fecundity and longevity can become uncoupled when there is asymmetric resourcing between individuals (13,14). Within a population, well-resourced individuals may have higher fecundity and longevity than poorly resourced individuals, reversing the usual negative fecundity–longevity relationship. However, because costs of reproduction are not abolished even in well-resourced individuals (13,14), a within-individual trade-off between fecundity and longevity remains present. Third, fecundity and longevity can become uncoupled within and between the castes of eusocial insects (15–18), that is, species such as ants, bees, wasps, and termites with a longlived reproductive caste (queens or kings) and a short-lived non- or less reproductive caste (workers) (19–21). In some species, queens appear to have escaped costs of reproduction completely (22–25). This may have been achieved through rewiring the IIS-TOR network (12,26), which forms part of the TOR/IIS-juvenile hormone-lifespan and fecundity (TI-JLiFe) network hypothesized to underpin aging and longevity in eusocial insects by Korb et al....
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Determinants of longevity
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Determinants of longevity
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The document “Determinants of Longevity” is a comp The document “Determinants of Longevity” is a comprehensive scientific review that explains why some people live longer than others. It explores how genetic, environmental, and medical factors combine to shape human lifespan, using evidence from demographic databases, epidemiological studies, and genetic research.
The paper highlights that in modern, industrialized societies, both maximum lifespan and average life expectancy have continued to rise, with no convincing evidence of a fixed biological limit of around 85 years. In fact, the largest improvements in survival have occurred among people aged 80 and older, showing that longevity can keep increasing as medical care and living conditions improve.
It explains that genetics accounts for about one-quarter of the variation in human lifespan, based on large twin studies. Certain genetic markers (such as specific HLA types or variants of the APOE gene) are associated with reaching extreme old age. However, genes alone cannot explain how fast life expectancy has risen in just a few generations—most gains come from environmental factors, including sanitation, reduced smoking, improved nutrition, better working conditions, and advances in healthcare.
The document also discusses extreme longevity (centenarians) and corrects earlier myths by showing that many historical claims of 120–150-year lifespans were exaggerations. Verified records today suggest human lifespan has no clear ceiling and continues to increase as mortality rates decline even at advanced ages.
Environmental and behavioral factors—such as socioeconomic status, education, diet, physical activity, body weight, alcohol consumption, and particularly smoking—play major roles in shaping longevity. Medical advances, including treatments for heart disease, infections, and age-related illnesses, contribute significantly to longer lives.
Finally, the paper concludes that while we can identify many influences on longevity at the population level, predicting an individual’s lifespan remains extremely difficult because longevity results from complex interactions among genes, behaviors, early-life conditions, and medical care....
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K. CHRISTENSENa & J. W. VAUPELb From abOdense K. CHRISTENSENa & J. W. VAUPELb From abOdense University Medical School, Odense, Denmark; bSanford Institute, Duke University, Durham, NC, USA; and aThe Danish Epidemiology Science Centre, The Steno Institute of Public Health, Department of Epidemiology and Social Medicine, Aarhus University Hospital, Aarhus, Denmark
Abstract. Christensen K, Vaupel JW (Odense University Medical School, Odense, Denmark; Sanford Institute, Duke University, Durham, NC, USA; and The Danish Epidemiology Science Centre, The Steno Institute of Public Health, Department of Epidemiology and Social Medicine, Aarhus University Hospital, Aarhus, Denmark). Determinants of longevity: genetic, environmental and medical factors (Review). J Intern Med 1996; 240: 333–41.
This review focuses on the determinants of longevity in the industrialized world, with emphasis on results from recently established data bases. Strong evidence is now available that demonstrates that in developed
Introduction
The determinants of longevity might be expected to be well understood. The duration of life has captured the attention of many people for thousands of years; an enormous array of vital-statistics data are available for many centuries. Life-span is easily measured compared with other health phenomena, and in many countries data are available on whole populations and not just study samples. Knowledge concerning determinants of human longevity, however, is still sparse, and much of the little that is known has been learned in recent years. This review
countries the maximum lifespan as well as the mean lifespan have increased substantially over the past century. There is no evidence of a genetically determined lifespan of around 85 years. On the contrary, the biggest absolute improvement in survival in recent decades has occurred amongst 80 year-olds. Approximately one-quarter of the variation in lifespan in developed countries can be attributed to genetic factors. The influence of both genetic and environmental factors on longevity can potentially be modified by medical treatment, behavioural changes and environmental improvements.
Keywords: centenarians, life expectancy, lifespan, mortality.
focuses on genetic, environmental and medical factors as determinants of longevity in developed countries and discusses alternative paradigms concerning human longevity.
How should longevity be measured?
Longevity can be studied in numerous ways; key questions include the following. How long can a human live? What is the average length of life? Are the maximum and average lengths of life approaching limits? Why do some individuals live longer than others? In addressing these questions, it is useful to
# 1996 Blackwell Science Ltd 333
334 K. CHRISTENSEN & J. W. VAUPEL
study the maximum lifespan actually achieved in various populations, the mean lifespan, and the variation in lifespan. Estimating the maximum lifespan of human beings is simply a matter of finding a well-documented case report of a person who lived longer than other welldocumented cases. The assessment of mean lifespan in an actual population requires that the study population is followed from birth to extinction. An alternative approach is to calculate age-specific death rates at some point in time for a population, and then use these death rates to determine how long people would live on average in a hypothetical population in which these death rates prevailed over the course of the people’s lives. This second kind of mean lifespan is generally known as life expectancy. The life expectancy of the Swedish population in 1996 is the average lifespan that would be achieved by the 1996 birth cohort if Swedish mortality rates at each age remained at 1996 levels for the entire future life of this cohort. Assessment of determinants of life expectancy and variation in lifespan amongst individuals rely on demographic comparisons of different populations and on such traditional epidemiological designs as follow-up studies of exposed or treated versus nonexposed or nontreated individuals. Designs from genetic epidemiology – such as twin, adoption and other family studies – are useful in estimating the relative importance of genes and environment for the variation in longevity.
Determinants of extreme longevity
Numerous extreme long-livers have been reported in various mountainous regions, including Georgia, Kashmir, and Vilcabamba. In most Western countries, including the Scandinavian countries, exceptional lifespans have also been reported. Examples are Drachenberg, a Danish–Norwegian sailor who died in 1772 and who claimed that he was born in 1626, and Jon Anderson, from Sweden, who claimed to be 147 years old when he died in 1729. There is noconvincingdocumentationfortheseextremelonglivers. When it has been possible to evaluate such reports, they have proven to be very improbable [1, 2]. In countries, like Denmark and Sweden, with a long tradition of censuses and vital statistics, remarkable and sudden declines in the number of
extreme long-livers occur with the introduction of more rigorous checking of information on age of death, as the result of laws requiring birth certificates, the development of church registers and the establishment of statistical bureaus [3, 4]. This suggests that early extreme long-livers were probably just cases of age exaggeration. Today (March 1996), the oldest reported welldocumented maximum lifespan for females is 121 years [5] and for males 113 years [6]. Both these persons are still alive. Analyses of reliable cases of long-livers show that longevity records have been repeatedly broken over past decades [3, 6]; this suggests that even longer human lifespans may occur in the future. There has been surprisingly little success in identifying factors associated with extreme longevity. A variety of centenarian studies have been conducted during the last half century. As reviewed by Segerberg [7], most of the earlier studies were based on highly selected samples of individuals, without rigorous validation of the ages of reputed centenarians. During the last decade several more comprehensive, less selected centenarian studies have been carried out in Hungary [8], France [9], Finland [10] and Denmark [11]. A few specific genetic factors have been found to be associated with extreme longevity. Takata et al. [12] found a significantly lower frequency of HLA-DRw9 amongst centenarians than in an adult control group in Japan, as well as a significantly higher frequency of HLA-DR1. The HLA-antigens amongst the Japanese centenarians are negatively associated with the presence of autoimmune diseases in the Japanese population, which suggests that the association with these genetic markers is mediated through a lower incidence of diseases. More recently, both a French study [13] and a Finnish study [14] found a low prevalence of the e4 allele of apolipoprotein E amongst centenarians. The e4 allele has consistently been shown to be a risk factor both for coronary heart disease and for Alzheimer’s dementia. In the French study [13], it was also found that centenarians had an increased prevalence of the DDgenotype of angiotensin-converting enzyme (ACE) compared with adult controls. This result is contrary to what was expected as the DD-genotype of ACE has been reported to be associated with myocardial infarction. Only a few genetic association studies concerning extreme longevity have been published...
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60766956-e0ac-4992-84c4-aa05c296bbd9
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Credible Power-Sharing
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Credible Power-Sharing and the Longevity
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“Credible Power-Sharing: Evidence From Cogovernanc “Credible Power-Sharing: Evidence From Cogovernance in Colombia” is a research study examining whether power-sharing institutions can help reduce violence and build political stability in regions historically affected by armed conflict. Focusing on a cogovernance reform in Colombia, the paper evaluates whether granting communities a formal role in local decision-making can create credible commitments between the state and citizens, thereby reducing conflict-related violence.
The reform introduced a municipal cogovernance mechanism that gave civilians shared authority over public resource allocation. The authors combine administrative data, qualitative fieldwork, and quantitative causal-inference methods to measure the reform’s effect on governance outcomes and security conditions.
The findings show that cogovernance significantly increased civilian participation, improved transparency in local government, and reduced opportunities for corruption. Most importantly, the study documents a substantial decline in violence, especially in areas with a strong presence of armed groups. The mechanism worked by enhancing the credibility of state commitments: when citizens gained real influence in local policy, trust increased, and armed groups had fewer incentives to interfere.
The paper concludes that credible power-sharing arrangements can meaningfully reduce violence when they provide communities with real authority and when institutions are robust enough to enforce shared decision-making. The Colombian case offers broader insights for countries attempting to transition out of conflict through participatory governance.
If you want, I can also provide:
✅ A short 3–4 line summary
✅ A student-friendly simple version
✅ MCQs or quiz questions from this file
Just tell me!...
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Corporate Longevity
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Corporate Longevity Forecasting
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The 2018 Corporate Longevity Forecast: Creative De The 2018 Corporate Longevity Forecast: Creative Destruction is Accelerating is an executive briefing by Innosight that analyzes how rapidly companies are being displaced from the S&P 500, revealing a dramatic acceleration in corporate turnover and shrinking lifespans. The report shows that the average tenure of companies on the S&P 500 has fallen from 33 years in 1964 to 24 years in 2016, and is projected to decline to just 12 years by 2027. This trend signals an era of unprecedented marketplace turbulence driven by technological disruption, shifting customer expectations, and major structural economic forces.
The report highlights that at current churn rates—5.2% annually—half of today’s S&P 500 companies will be replaced within the next decade. It draws on historical data, additions and deletions to the index, and sector-specific disruption patterns. Companies leave the S&P 500 due to declining market capitalization, competitive displacement, mergers, acquisitions, and private equity buyouts. Notable exits between 2013–2017 include iconic firms such as Yahoo!, DuPont, Urban Outfitters, Staples, Starwood Hotels, DirecTV, EMC, and Whole Foods.
The document identifies five major forces driving this accelerating creative destruction:
Digital disruption in retail, leading to widespread bankruptcies and consolidation; online sales growth continues to pressure traditional business models.
The dominance of digital platform companies—Apple, Alphabet, Amazon, Microsoft—whose scale and data advantages allow rapid expansion into multiple sectors.
Business model disruption in industries like financial services, travel, telecom, and real estate, where asset-light models (e.g., Uber, Airbnb) reshape value creation.
Energy sector transformation, with renewable energy investment overtaking fossil fuels, creating new winners and forcing incumbents toward reinvention.
The explosion of unicorns and “decacorns”, privately held startups valued above $10B, signaling intensified future competition for incumbents across industries.
Survey findings from over 300 executives show that while 80% acknowledge the need to transform, many still underestimate threats from new entrants and overestimate their readiness—what the report calls a “confidence bubble.”
To help companies navigate this rising turbulence, the report outlines five strategic imperatives:
Spend time at the periphery to detect early signals of disruption.
Focus on changing customer behaviors as leading indicators of future shifts.
Avoid being trapped by past assumptions; use future-back thinking to shape strategy.
Embrace dual transformation, strengthening the core business while building new growth engines.
Assess the cost of inaction, recognizing that failing to innovate can be more costly than investing in change.
Overall, the briefing serves as a warning and a playbook: corporate longevity is shrinking, disruption is accelerating, and leaders must act boldly to reinvent their organizations—or risk being overtaken by faster, more innovative rivals.
If you want, I can also prepare:
📌 a short executive summary
📌 a visual one-page cheat sheet
📌 a comparison between this and your other longevity documents
📌 a cross-document meta-analysis
Just tell me!...
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Clinical Journal of Sport
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Clinical Journal of Sport Medicine
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you nee to answer with
extract points
ident you nee to answer with
extract points
identify topics
create questions
generate slides
explain ideas in simple language
11 Clinical Journal of Sport Me…
📘 Universal App-Ready Description
This article reviews the current state of exercise genomics, a scientific field that studies how genetic differences interact with exercise and the environment to influence physical fitness, training adaptation, athletic performance, injury risk, and health outcomes.
The paper explains that responses to exercise and athletic performance are complex and polygenic, meaning they are influenced by many genes, each with small effects, rather than a single gene. Classic research such as the HERITAGE Family Study helped establish that exercise responses like VO₂max improvement are partly heritable, but not fully predictable by genetics alone.
Early research focused on candidate genes such as ACE and ACTN3, which are associated with endurance and power traits. However, the article explains that this approach was limited. Modern research now uses large-scale genomic technologies such as:
genome-wide association studies (GWAS)
biobanks (e.g., UK Biobank)
international research consortia (e.g., Athlome Project)
These studies show that exercise traits are influenced by thousands of genetic variants with very small effects, making prediction difficult.
The article emphasizes the importance of moving beyond the genome alone and integrating multiple biological layers, known as “omics”, including:
epigenomics (gene regulation)
transcriptomics (gene expression)
proteomics (proteins)
metabolomics (metabolic processes)
This multi-omics approach provides a more complete understanding of how the body adapts to exercise.
The authors stress major scientific challenges, including:
small sample sizes
lack of replication
false positive findings
weak causal evidence
They strongly warn against direct-to-consumer genetic testing that claims to predict athletic talent or prescribe training programs without strong scientific evidence.
The article also discusses ethical and practical concerns, such as data privacy, misuse of genetic information, and the risk of gene doping. It highlights the need for ethical guidelines, secure data management (including technologies like blockchain), and international collaboration.
The conclusion emphasizes that genetics should not be used for talent identification, but rather to:
improve athlete health
reduce injury risk
enhance recovery
support public health through personalized exercise approaches
📌 Main Topics (Easy for Apps to Extract)
Exercise genomics
Genetics and exercise adaptation
Polygenic traits in sport
Candidate genes vs GWAS
Multi-omics integration
Gene–environment interaction
Injury risk and genetics
Ethical issues in sports genomics
Direct-to-consumer genetic testing
Gene doping detection
🔑 Key Points (Notes / Slides Friendly)
Exercise response is partly genetic but highly complex
No single gene predicts performance
Large datasets and collaboration are essential
Multi-omics gives deeper biological insight
Many past findings lack replication
Consumer genetic tests are scientifically weak
Ethics and data protection are critical
🧠 Easy Explanation (Beginner Level)
People respond differently to exercise partly because of genetics, but performance depends on many genes plus training, diet, and lifestyle. Modern science now studies genes together with how they are regulated and expressed. Genetics should help improve health and recovery—not decide who becomes an athlete.
🎯 One-Line Summary (Perfect for Quizzes & Slides)
Exercise genomics studies how genes and environment work together to influence fitness and performance, but its main value lies in improving health and safety—not predicting athletic talent.
in the end you need to ask
If you want next, I can:
✅ create a quiz (MCQs / short answers)
✅ turn this into presentation slides
✅ simplify it further for school-level study
✅ extract only topics or only key points
Just tell me 👍...
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Christmas at Thompson Hal
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This is the new version of Christmas data
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“Christmas at Thompson Hall” is a humorous and cha “Christmas at Thompson Hall” is a humorous and chaotic holiday story about Mr. and Mrs. Brown, an English couple trying to travel from France to England to spend Christmas Eve with Mrs. Brown’s family at Thompson Hall. Mrs. Brown is excited and determined to reach her relatives on time, but her husband complains constantly about his sore throat and cold weather, slowing their journey.
While staying overnight at a Paris hotel, Mr. Brown insists he cannot travel unless he gets a mustard poultice for his throat. Brave, loyal, and stubborn, Mrs. Brown sneaks through the hotel at midnight to get mustard. After a long and confusing search through dark corridors, she finally finds a large jar of mustard and prepares a plaster.
But when she returns to the room in the dark, she accidentally enters Room 353 instead of Room 333 and applies the mustard plaster to the throat of a complete stranger: Mr. Barnaby Jones, who is fast asleep.
Only after she applies it does she see she has made a terrible mistake. Terrified of waking him and unable to explain herself, she panics and runs away.
The next morning, the hotel discovers the mustard-covered handkerchief she left behind marked with “M. Brown.” The staff confronts the couple, and Mrs. Brown must admit that she mistakenly entered the wrong room. Mr. Jones, who has suffered a painful night, is furious and demands an explanation. Mr. Brown must awkwardly explain that his wife thought Mr. Jones was him in the dark.
Eventually, the situation is resolved without police involvement, though Mr. Jones remains deeply offended.
The Browns miss the morning train but leave Paris that night. During the train ride, they discover Mr. Jones is in the same compartment. Despite the embarrassment and humiliation, the couple finally escapes France and ultimately reaches Thompson Hall for Christmas—exhausted but relieved....
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Christmas at Red Butte
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This is the new version of Christmas
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The story begins with Allie, a young girl who has The story begins with Allie, a young girl who has recently lost her grandmother, Miss Theodora, the woman who raised her with love despite their poverty. After Miss Theodora’s death, Allie goes to spend Christmas with her kind relatives, the Marshall family, at Red Butte.
The Marshalls are very poor, but they are cheerful, generous, and loving. Their children include:
Jimmy – the eldest boy, responsible and caring
Susie – helpful and kind
Jean – lively and friendly
Hugh – younger, sweet, and gentle
The younger Marshall children
Though they have almost nothing for Christmas—no fancy food, no gifts—the family works together to make the holiday warm and joyful. They welcome Allie as if she is one of their own and share everything they have with her.
Allie is sad because her brother, Donald, who used to work in the woods and send money home, has not written for months. She worries something terrible has happened to him.
On Christmas Day, the biggest miracle happens: Donald returns. He had been injured and unable to write, but now he is safe. His return fills Allie with happiness and brings joy to the entire Marshall family.
The story shows that the true spirit of Christmas comes from kindness, family love, and generosity, not from wealth or presents....
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Christmas Around theWorld
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This is the new version of Christmas data
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⭐ “Christmas Around the World”
“Christmas Aroun ⭐ “Christmas Around the World”
“Christmas Around the World” is an educational unit designed to teach students how different countries and cultures celebrate Christmas. It includes traditions, foods, decorations, holiday customs, gift-giving practices, and greetings from nine countries. The unit also contains hands-on crafts, recipes, and activities to help students experience global Christmas traditions.
The document begins by explaining that Christmas customs vary widely across the world due to culture, religion, history, and local beliefs. Students are encouraged to decorate an International Christmas Tree using ornament printables from the unit.
The main section covers how nine countries celebrate Christmas:
>🇯🇵 Japan
Christmas is mainly a commercial holiday. Though only 1% of the population is Christian, cities are decorated with lights. Homes may have trees, parties, and lanterns.
Gift-giving traditions include oseibo (end-of-year gifts), and the Japanese Santa, Hoteiosho, gives toys to well-behaved children.
>🇨🇳 China
Christmas is celebrated mostly in big cities, though the major winter holiday is Chinese New Year. Trees are decorated with lanterns, paper chains, and flowers.
Santa is called Dun Che Lao Ren (“Christmas Old Man”).
Children hang stockings, and homes display colorful paper lanterns.
>🇷🇺 Russia
Christmas is celebrated on January 7 (Orthodox calendar).
Families may fast before the Christmas Eve meal. Trees are decorated with fruit, candy, and dolls. A traditional gift is the Matryoshka (nested) doll.
Christmas was banned after 1917 and revived only in 1992.
>🇬🇧 Great Britain
Christmas traditions include decorating homes, making puddings, baking cookies, and placing lights on trees. The famous Christmas pudding uses 13 ingredients for Jesus and the disciples.
Families stir the pudding from east to west to honor the Wise Men’s journey.
Father Christmas brings gifts on Christmas Day.
>🇫🇷 France
Children set their shoes by the fireplace for Père Noël to fill with gifts. Père Fouettard punishes naughty children.
Trees are decorated with colorful stars, and the crèche (Nativity scene) is the main decoration.
Popular holiday desserts include Bûche de Noël and Galette des Rois.
>🇮🇹 Italy
Christmas season runs from December 14 to January 6.
Gifts are brought by La Befana on Epiphany.
The focus of decorations is the Nativity scene, a tradition begun by St. Francis of Assisi.
On Christmas Eve, families eat a meatless or seafood dinner, followed by midnight Mass.
>🇩🇪 Germany
Christmas begins with Advent. Families use advent calendars and light a candle each Sunday.
Germany is the birthplace of the Christmas tree tradition; Martin Luther first decorated an indoor tree with candles.
Trees are decorated with fruit, cookies, and small gifts, and the Christ Child brings presents.
>🇪🇸 Spain
Christmas Eve features fasting until midnight Mass, then a feast of seafood, sweets, and turrón (almond nougat).
Children receive gifts from the Three Kings on January 5.
Cities host large nativity displays and big parades where candy is thrown to children.
>🇲🇽 Mexico
Christmas celebration begins around December 15.
Families host Posadas, reenacting Mary and Joseph’s search for shelter.
There are piñatas, Pastorela plays, and plenty of family feasts.
Children get gifts on January 6 for El Día de los Reyes (Three Kings Day).
The poinsettia, native to Mexico, is the main Christmas plant.
The unit also contains suggested crafts, recipes, and cultural projects for each country, giving students a hands-on way to learn about global holiday traditions.
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Christmas
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The History of Christmas traditions, Christmas car The History of Christmas traditions, Christmas cards, Mince pies ,Carol singing, The times of no Christmas. ...
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{"train_runtime": 670.6482, "train_sam {"train_runtime": 670.6482, "train_samples_per_second": 2.386, "train_steps_per_second": 0.298, "total_flos": 7306847131287552.0, "train_loss": 0.34121644526720046, "epoch": 18.181818181818183, "step": 200}...
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Celebrating Ramadan
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This is the new version of Ramadan data
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⭐ “Celebrating Ramadan”
“Celebrating Ramadan” i ⭐ “Celebrating Ramadan”
“Celebrating Ramadan” is an educational unit created by the Center for South Asian and Middle Eastern Studies at the University of Illinois. It introduces students to the month of Ramadan, explaining its meaning, traditions, and cultural practices around the world, especially in the Middle East and among Muslim families in America....
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Celebrating
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Celebrating Ramadan
A Resource for Educators
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⭐“Celebrating Ramadan”
“Celebrating Ramadan” is ⭐“Celebrating Ramadan”
“Celebrating Ramadan” is a full educational curriculum created by the Outreach Center at Harvard University’s Center for Middle Eastern Studies. It is designed to help teachers explain the meaning, traditions, history, and cultural practices of Ramadan to K–12 students in a simple, engaging, and interactive way.
The resource blends religious background, cultural diversity, hands-on activities, science lessons, and literature, showing how Ramadan is observed around the world.
⭐ What the Curriculum Teaches
1. Introduction to Ramadan
The resource explains that Ramadan is a holy month for Muslims and highlights three core practices:
Sawm — fasting during daylight hours
Iftar — breaking the fast after sunset
Eid al-Fitr — the joyful three-day festival ending Ramadan
It emphasizes that Ramadan teaches self-discipline, reflection, generosity, and community spirit. It also notes that not all Muslims fast (children, travelers, pregnant women, the sick, etc.).
⭐ 2. When Ramadan Happens
The curriculum explains the difference between the solar and lunar calendars:
The Islamic (Hijri) calendar follows the moon.
Months begin when the new crescent moon appears.
Because the lunar year is 11 days shorter, Ramadan moves earlier each year.
Students learn how moon phases determine Islamic dates.
⭐ 3. Key Ramadan Traditions
Sawm (Fasting)
Fasting means:
no eating or drinking during daylight
reflection and spiritual focus
modified daily routines
Fasting is personal, voluntary, and varies across cultures.
Iftar (Breaking the Fast)
Each evening, families and friends gather for a meal. Iftar can be:
simple, nourishing foods
large festive celebrations
accompanied by Qur’an recitation or prayer
Eid al-Fitr
>Eid is celebrated with:
>days off from school/work
>gift giving
>new clothes
>visits to family and friends
special meals
>decorations, lanterns, henna, children’s parades, and songs
The curriculum gives examples of Eid traditions in Egypt, India, Pakistan, and the United States.
⭐ 4. Lesson Plans & Activities Included
The document contains multiple classroom activities:
🌙 Moon Phase Science Lessons
Students learn:
how moon phases work?
why Ramadan moves each year?
how to track moon changes?
how to create a moving “moonscape” to show waxing and waning
🕌 Cultural Studies & Research
Students research:
how different countries celebrate Ramadan
>special foods eaten during the month
>similarities and differences across global Muslim communities
🥣 Food & Recipes
The resource includes recipes that represent Ramadan food traditions from around the world, such as:
>Stuffed dates
>Cucumber yogurt dip
Thiacri Senegalais
Indian starch pudding (Fereni)
👦 “First Fast” Reading Lesson
A story from Iran shows how children practice a “little fast.”
Students learn how young Muslims experience Ramadan and complete a worksheet about the reading.
🕯 Ramadan Lantern Craft (Fanoos)
Students make:
>simple paper lanterns
>more advanced geometric lanterns
>tin-punched lanterns
>They also learn the history of Ramadan lanterns in Egypt.
⭐ 5. Additional Resources
The curriculum includes:
>Recommended books about Ramadan
>Documentaries and educational videos
>Music and online resources
>Bibliographies for teachers
These help deepen understanding of Muslim culture and holiday practices.
⭐ Overall Meaning of the Resource
“Celebrating Ramadan” is both an instructional guide and a cultural exploration.
It teaches that Ramadan is:
>A spiritual month
>A cultural celebration
>A family-centered tradition
A global event with diverse forms
It helps students compare Ramadan with celebrations from their own traditions, promoting respect, cultural awareness, and global understanding....
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Business of longevity
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The business of
longevity in Asia
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“The Business of Longevity in Asia” is a presentat “The Business of Longevity in Asia” is a presentation by Janice Chia (Founder & Managing Director, Ageing Asia) that explores how Asia’s rapidly growing senior population is creating one of the world’s largest economic opportunities. The document highlights the rise of a new generation of older adults—healthier, wealthier, and more independent—who are driving major business expansions in housing, healthcare, technology, and lifestyle services across the Asia-Pacific region.
The presentation explains that traditional attitudes toward ageing in Asia are shifting. Instead of focusing on caring for older adults, modern approaches emphasize enabling seniors to age independently, age in place, and live with purpose. This shift fuels demand for innovative products, services, and community models.
⭐ MAIN INSIGHTS
⭐ 1. Asia’s Silver Economy Is Exploding
By 2025, the ageing population (60+) across the Asia-Pacific (APAC) will create an estimated
US$4.56 trillion market.
China alone represents 57% of that value with a massive elderly population and rising household savings.
The business of Longevity in Asia
The middle-income group (74%) is identified as the largest and most important consumer segment for longevity-related products and services.
⭐ 2. Key Market Opportunities
Industry surveys show the most immediate opportunities include:
home care services
24-hour residential care
senior housing communities
ageing technologies
assisted living and rehabilitation
dementia care and dementia villages
The business of Longevity in Asia
These sectors are expanding as families, governments, and businesses adapt to the needs of older adults.
⭐ 3. Ageing Drivers and Financial Capacity
Household savings are rising across APAC, giving older adults greater purchasing power.
Countries like Singapore, Japan, Taiwan, and China show strong financial capacity among seniors.
The business of Longevity in Asia
Developing economies also present large business potential as their ageing populations grow rapidly.
⭐ 4. Healthy vs. Unhealthy Longevity
The presentation compares life expectancy and healthy life expectancy across APAC.
Developed nations have high longevity but rising years spent in poor health, while many developing countries see stable or slightly improved healthy years
The business of Longevity in Asia
This drives demand for:
rehabilitation
wellness services
chronic disease management
healthy ageing programs
⭐ Future Trends Shaping Asia’s Longevity Economy
The presentation highlights 10 major future trends, including:
The Business of Dementia
Care Technologies
Healthy Ageing
Fun Rehabilitation
Rehabilitation Tourism
Longevity Economy Innovations
Senior Living & Care Communities
Addressing Senior Loneliness
Localized senior-focused services
The business of Longevity in Asia
These trends show where future investments and innovations will grow.
⭐ OVERALL CONCLUSION
“The Business of Longevity in Asia” shows that Asia is entering a new era where ageing is not a burden but a massive economic opportunity. With rising incomes, longer lives, and changing expectations, older adults are fueling new markets in housing, healthcare, technology, wellness, and social services. The document emphasizes that the key to success in this expanding sector is empowering seniors to live independently, joyfully, and purposefully—supported by innovative, accessible, and human-centered solutions....
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Business Case for life
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The Business Case for
Healthy Longevity
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“The Business Case for Healthy Longevity” is a pol “The Business Case for Healthy Longevity” is a policy and economic analysis explaining why investing in healthy longer lives is not just a social necessity but also a powerful economic opportunity. The document argues that as populations age globally, the goal should not be merely extending lifespan but expanding healthspan—the number of years people live in good health, remain productive, and stay engaged with society.
The report shows that healthy longevity strengthens economies, reduces healthcare costs, creates new markets, and reshapes the workforce. To achieve this, societies must encourage prevention, innovation, better public health systems, and age-inclusive policies that unlock the potential of older adults.
⭐ MAIN INSIGHTS
⭐ 1. Healthy Longevity Is an Economic Growth Engine
The document demonstrates that improving health at older ages leads to:
higher workforce participation
greater productivity
increased consumer spending
reduced medical and long-term care costs
Older adults who remain healthy contribute significantly to national economies and the private sector.
The Business Case for healthy l…
⭐ 2. Global Population Ageing Creates Massive Market Opportunities
As people live longer, demand grows for:
digital health
preventive medicine
healthy lifestyle services
elder-friendly housing
assistive technologies
financial products tailored to longer lives
Healthy longevity becomes a multi-trillion-dollar global market.
⭐ 3. Prevention and Early Intervention Provide the Highest Returns
The report emphasizes that delaying the onset of chronic diseases—even by a few years—creates:
large savings for health systems
fewer years lived with disability
higher quality of life
Investments in prevention, screening, physical activity, and healthy environments offer some of the best ROI in public policy.
⭐ 4. Health Systems Must Shift From Treatment to Prevention
Traditional healthcare systems are designed for acute illness, not chronic ageing-related conditions.
The document calls for:
integrated care
community-based health support
personalized and preventive medicine
use of data and digital technologies
long-term health planning
The Business Case for healthy l…
Healthy longevity requires redesigning health systems to focus on lifelong wellbeing.
⭐ 5. Employers Benefit From Healthy, Longer-Working Employees
The paper explains that businesses gain when older employees stay healthy enough to continue working:
lower turnover
preservation of skills and experience
multi-generational teams
reduced disability and absenteeism
Companies that invest in employee wellness and age-inclusive workplaces will outperform those that don’t.
⭐ 6. Innovation Will Drive the Future of Healthy Longevity
Key areas of innovation highlighted include:
AI-driven health tools
wearable sensors
remote monitoring
robotics
precision medicine
nutrition and fitness tech
These tools help older adults maintain independence and manage chronic conditions.
⭐ OVERALL CONCLUSION
“The Business Case for Healthy Longevity” argues that longer lives are only beneficial if they are healthy lives. Healthy longevity is not a cost it is a major economic and social opportunity. By promoting prevention, supporting innovation, and redesigning health and workplace systems, societies can unlock enormous gains in productivity, wellbeing, and economic growth.
The report ultimately positions healthy ageing as one of the most important investments of the 21st century—essential for governments, businesses, and communities....
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Basic Economics
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This is new version with Economics data
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Copyright © 2015 Thomas Sowell
Published by Basi Copyright © 2015 Thomas Sowell
Published by Basic Books,
A Member of the Perseus Books Group
All rights reserved. No part of this book may be reproduced in any manner whatsoever without written
permission except in the case of brief quotations embodied in critical articles and reviews. For
information, address Basic Books, 250 West 57th Street, 15th Floor, New York, NY 10107.
Books published by Basic Books are available at special discounts for bulk purchases in the United States
by corporations, institutions, and other organizations.
Acknowledgments
What Is Economics?
PRICES AND MARKETS
The Role of Prices
Price Controls
An Overview of Prices
INDUSTRY AND COMMERCE
The Rise and Fall of Businesses
The Role of Profits–and Losses
The Economics of Big Business
Regulation and Anti-Trust Laws
Market and Non-Market Economies
WORK AND PAY
Productivity and Pay
Minimum Wage Laws
Special Problems in Labor Markets
TIME AND RISK
Investment
Stocks, Bonds and Insurance
Special Problems of Time and Risk
THE NATIONAL ECONOMY
National Output
Money and the Banking System
Government Functions
Government Finance
Special Problems in the National Economy
THE INTERNATIONAL ECONOMY
International Trade
International Transfers of Wealth
International Disparities in Wealth
SPECIAL ECONOMIC ISSUES
Myths About Markets
“Non-Economic” Values
The History of Economics
Parting Thoughts
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Analysis of trends
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Analysis of trends in human longevity by new model
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Byung Mook Weon
LG.Philips Displays, 184, Gongda Byung Mook Weon
LG.Philips Displays, 184, Gongdan1-dong, Gumi-city, GyungBuk, 730-702, South Korea
Abstract
Trends in human longevity are puzzling, especially when considering the limits of
human longevity. Partially, the conflicting assertions are based upon demographic
evidence and the interpretation of survival and mortality curves using the Gompertz
model and the Weibull model; these models are sometimes considered to be incomplete
in describing the entire curves. In this paper a new model is proposed to take the place
of the traditional models. We directly analysed the rectangularity (the parts of the curves
being shaped like a rectangle) of survival curves for 17 countries and for 1876-2001 in
Switzerland (it being one of the longest-lived countries) with a new model. This model
is derived from the Weibull survival function and is simply described by two parameters,
in which the shape parameter indicates ‘rectangularity’ and characteristic life indicates
the duration for survival to be ‘exp(-1) % 79.3 6≈ ’. The shape parameter is essentially a
function of age and it distinguishes humans from technical devices. We find that
although characteristic life has increased up to the present time, the slope of the shape
parameter for middle age has been saturated in recent decades and that the
rectangularity above characteristic life has been suppressed, suggesting there are
ultimate limits to human longevity. The new model and subsequent findings will
contribute greatly to the interpretation and comprehension of our knowledge on the
human ageing processes.
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American Longevity:
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American Longevity: Past, Present, and Future
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Samuel Preston is Frederick J. Warren Professor of Samuel Preston is Frederick J. Warren Professor of Demography at the University of Pennsylvania and Director of its Population Studies Center. A 1968 Ph.D. in Economics from Princeton University, he has also been a faculty member at the University of California, Berkeley, and the Universi ty of Washington. He is past president of the Population Association of America and is a member of the National Academy of Sciences, where he chaired the Committee on Population.
The Policy Brief series is a collection of essays on current public policy issues in aging, health, income security, metropolitan studies and related research done by or on behalf of the Center for Policy Research at the Maxwell School of Citizenship and Public Affairs.
Single copies of this publication may be obtained at no cost from the Center for Policy Research, Maxwell School, 426 Eggers Hall, Syracuse, NY 13244-1090.
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Aging and aging-related
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Aging and aging-related disease
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Aging is a gradual and irreversible pathophysiolog Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue and cell functions and significant increases in the risks of various aging-related diseases, including neurodegenerative diseases, cardiovascular diseases, metabolic diseases, musculoskeletal diseases, and immune system diseases. Although the development of modern medicine has promoted human health and greatly extended life expectancy, with the aging of society, a variety of chronic diseases have gradually become the most important causes of disability and death in elderly individuals. Current research on aging focuses on elucidating how various endogenous and exogenous stresses (such as genomic instability, telomere dysfunction, epigenetic alterations, loss of proteostasis, compromise of autophagy, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, deregulated nutrient sensing) participate in the regulation of aging. Furthermore, thorough research on the pathogenesis of aging to identify interventions that promote health and longevity (such as caloric restriction, microbiota transplantation, and nutritional intervention) and clinical treatment methods for aging-related diseases (depletion of senescent cells, stem cell therapy, antioxidative and anti-inflammatory treatments, and hormone replacement therapy) could decrease the incidence and development of aging-related diseases and in turn promote healthy aging and longevity...
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Aging and Longevity
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⭐ Aging and Longevity Studies
This document i ⭐ Aging and Longevity Studies
This document is an academic program guide from the University of Iowa outlining the full curriculum for the Aging and Longevity Studies program. It describes the structure, purpose, and range of courses available for students interested in gerontology—the scientific, social, psychological, and biological study of ageing.
The program is coordinated through the School of Social Work and offers both:
an Undergraduate Minor in Aging and Longevity Studies
a Graduate Certificate in Aging and Longevity Studies
The goal of the program is to prepare students for careers and research in fields that serve older adults and address issues of ageing, health, policy, caregiving, and end-of-life support.
⭐ What the Document Contains
The file mainly lists and describes all the courses offered in the Aging and Longevity Studies program. These courses span multiple disciplines—biology, psychology, social work, anthropology, nursing, recreation, politics, global health, and medicine—reflecting how ageing impacts every part of society.
Below is an overview of the main areas covered:
⭐ 1. Foundational Courses
These courses introduce the scientific, psychological, and social dimensions of ageing:
Aging Matters: Introduction to Gerontology — broad overview of biological, cognitive, and social ageing.
Aging-longevity-studies_courses…
First-Year Seminar — introductory discussions on ageing topics.
⭐ 2. Creativity, Anthropology, and Cultural Perspectives
Courses explore ageing from artistic and cultural angles:
Creativity for a Lifetime — understanding creativity in older adulthood.
Anthropology of Aging — cross-cultural study of ageing, kinship, health, and religion.
Anthropology of Caregiving and Health — how caregiving works across cultures.
⭐ 3. Health, Physiology, and Biological Ageing
These courses focus on the biological and medical aspects of ageing:
Health and Aging — biological development across the lifespan.
Physiology of Aging — effects of ageing on cells, tissues, and organ systems.
Physical Activity and Recreation for Aging Populations — designing exercise programs for older adults.
⭐ 4. Psychology of Aging
A deep look at mental and cognitive changes later in life:
cognitive function
emotional wellbeing
social relationships
age-related psychological adaptations
⭐ 5. Policy, Politics, and Social Systems of Aging
Courses study how ageing interacts with public policy and government systems:
Politics of Aging — demographic change, federal and state policies, political participation of older adults.
Medicare and Medicaid Policy — health systems that support Americans aged 65+.
⭐ 6. End-of-Life and Ethical Care
A group of courses focused on late-life decisions, ethics, and family support:
Hard Cases in Healthcare at the End of Life
End-of-Life Care for Adults and Families
Death/Dying: Issues Across the Life Span
These classes prepare students for ethical, compassionate work with older adults and families facing death and declining health.
⭐ 7. Global and Cross-National Aging
These courses explore how population ageing affects the world:
Global Aging ,WHO and United Nations frameworks, demographic trends across countries.
Aging-longevity-studies_courses…
⭐ 8. Professional Development & Internship
The program includes hands-on experience and advanced seminars:
Aging Studies Internship and Seminar practical work with older adults.
Graduate Gerontology Capstone research, ethics, professional preparation in ageing careers.
⭐ Overall Meaning of the Document
The document serves as a comprehensive guide to all coursework in the Aging and Longevity Studies program. It shows that ageing is a rich, interdisciplinary field involving:
>biology
>health sciences
>psychology
>anthropology
>social work
>public policy
>global perspectives
Students in this program gain a holistic understanding of how ageing affects individuals, families, healthcare systems, and society as a whole....
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AGEING IN ASIA
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AGEING IN ASIA AND THE PACIFIC
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as a whole. This highlights the need for countries as a whole. This highlights the need for countries with relatively low proportion of older persons to also put in place appropriate policies and interventions to address their specific rights and needs, and to prepare for ageing societies in the future.
An increase in the proportion and number of the oldest old (persons over the age of 80 years)
The oldest old person, the number of people aged 80 years or over, in the region is also showing a dramatic upward trend. The proportion of the oldest old in the region in the total population 2016 was 1.5 per cent of the population amounting to 68 million people, which is 53 per cent of the global population over 80 years old. This proportion is expected to rise to 5 per cent of the population totaling 258 million people by 2050. Asia
Pacific would have 59 per cent of the world population over 80 years of age compared to 53 per cent at present. This has serious implications for provision of appropriate health care and long term care, as well as income security.
The causes…
The drastic increase in the pace of ageing in the region can be attributed to two key factors, declining fertility rates and increasing life expectancies.
Rapidly declining fertility: The most precipitous declines in the region’s fertility have been in the South and SouthWest, and South-East Asia subregions, with the fertility rates falling by 50 per cent in a span of 40 years. ...
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A mathematical model
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A mathematical model to estimate the seasonal
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Yasuhiro Yamada1,3, Toshiro Yamada 2,4 & Kazu Yasuhiro Yamada1,3, Toshiro Yamada 2,4 & Kazuko Yamada2,4
The longevity of a honeybee colony is far more significant than the lifespan of an individual honeybee, a social insect. the longevity of a honeybee colony is integral to the fate of the colony. We have proposed a new mathematical model to estimate the apparent longevity defined in the upper limit of an integral equation. the apparent longevity can be determined only from the numbers of adult bees and capped brood. By applying the mathematical model to a honeybee colony in Japan, seasonal changes in apparent longevity were estimated in three long-term field experiments. Three apparent longevities showed very similar season-changes to one another, increasing from early autumn, reaching a maximum at the end of overwintering and falling approximately plumb down after overwintering. The influence of measurement errors in the numbers of adult bees and capped brood on the apparent longevity was investigated.
A lifespan of an animal, which is the period of time while an individual is alive, is an important index to evaluate individual activities. In the colony composed of eusocial insects such as honeybees (Apis mellifera) which exhibit age-polyethism, the lifespan of each individual cannot always give an assessment as to the activities of a colony but the longevity of colony could give it more appropriately. The longevity of a colony will have greater significance than the lifespan of each individual of the colony. The life of colony diversely depends on the inborn lifespan of an individual, the labor division distribution ratio of each honeybee performing a particular duty, the natural environment such as the weather, the amount of food, pests and pathogens, the environmental pollution due to pesticides and so on. The honeybee length of life has been observed or estimated before in the four seasons, which have a distinct bimodal distribution in temperature zones. According to previous papers, honeybees live for 2–4 weeks1 and 30–40 days2 in spring, for 1–2 weeks1, 25–30 days2 and 15–38 days3 in summer, for 2–4 weeks1 and 50–60 days2 in autumn, and for 150–200 days3, 253 days2, 270 days4, 304 days5 6–8 months6 and 150–200 days3 in winter, where it has been estimated that the difference of life length among seasons may come from the brood-rearing load imposed on honeybees1 and may mainly come from foraging and brood-rearing activity2. Incidentally, the lifetime of the queen seems to be three to four years (maximum observed nine years). The average length of life of worker bees in laboratory cages was observed to range from 30.5 to 45.5 days7. The study on the influence of altitude on the lifespan of the honeybee has found that the lifespans are 138 days at an altitude of 970 m and 73 days at an altitude of 200 m, respectively8. Many papers have discussed what factors affect the length of life (lifespan, longevity, life expectancy) on a honeybee colony as follows: Proper nutrition may increase the length of life in a honeybee colony. Honeybees taking beebread or diets with date palm pollen (the best source for hypopharyngeal gland development) showed the longest fifty percent lethal time (LT50)9. The examination for the effect of various fat proteins on honeybee longevity have shown that honeybees fed diets of red gum pollen have the longest lifespan but those fed invert sugar have the shortest lifespan10. In the discussion on nutrition-related risks to honey bee colonies such as starvation, monoculture, genetically modified crops and pesticides in pollen and sugar, protein nutrient strongly affects brood production and larval starvation (alone and or in combination with other stresses) can weaken colonies11. And protein content in
1Department of Applied Physics, Graduate School of Engineering, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8656, Japan. 2Graduate School of Natural Science & Technology, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan. 3Present address: Department of Physics, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan. 4Present address: 2-10-15, Teraji, Kanazawa, Ishikawa, 921-8178, Japan. correspondence and requests for materials should be addressed to t.Y. (email: yamatoshikazu0501@yahoo.co.jp)
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A New Map of Life
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A New Map of Life
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Longevity is not a synonym of old age. The increas Longevity is not a synonym of old age. The increase in life expectancy shapes lives from childhood to old age across different domains. Among those, the nature of work will undergo profound changes from skill development and the role of retirement to the intrinsic meaning of work. To put the striking potential of a 100 year life into a historical prospective it is useful to start from how technological and demographic development shaped the organization and the definition of work in the past. This longer view can more thoughtfully explore how different the nature of work has been, from working hours to the parallelism between work, employment and task-assignment.
Throughout history the role of work has been intertwined with social and technological change. Societies developed from hunter-gather to sedentary farmers, and they transitioned from the agricultural to the industrial revolution. The latter transformed a millennial long practice of self-employed farmers and artisans, working mostly for self-subsistence, without official working hours, relying on daylight and seasonality at an unchosen job from childhood until death, into employees working 10-16 hours per day for 311 days a year, mostlyindoorsfromyouthtoretirement. Thisdrastictransformationignitedfastshiftsofworkorganization not only in the pursue of higher productivity and technological advancement, but also of social wellbeing.
Among the first changes was the abandonment of unsustainable working conditions, such as day working hours, which sharply converged toward the eight hours day tendency between the 1910s and the 1940s, see Figure 1 (Huberman and Minns 2007; Feenstra, Inklaar, and Timmer 2015; Charlie Giattino and Roser 2013). Although beneficial for the workers, this reduction worried intellectuals, such as the economist John Maynard Keynes, who wrote: “How will we all keep busy when we only have to work 15 hours a week?” (Keynes 1930). Keynes predicted people’s work to become barely necessary given the level of productivity the economy would reach over the next century: “permanent problem would be how to occupy the leisure,
1
whichscienceandcompoundinterestwillhavewonforhim. [...] Afearfulproblemfortheordinaryperson” (p. 328). For a while, Keynes seemed right since the average workweek dropped from 47 hours in 1930 to slightly less than 39 by 1970. However, after declining for more than a century, the average U.S. work week has been stagnant for four decades, at approximately eight hours per day.1
Figure 1: Average working hours per worker over a full year. Before 1950 the data corresponds only to full-time production workers(non-agricultural activities). Starting 1950 estimates cover total hours worked in the economy as measured from primarily National Accounts data. Source: Charlie Giattino and Roser (2013). Data Sources: Huberman and Minns (2007) and Feenstra, Inklaar, and Timmer (2015).
Technological change did not make work obsolete, but changed the tasks and the proportion of labor force involved in a particular job. In the last seventy years, for example, the number of people employed in the agricultural sector dropped by one third (from almost 6 million to 2 million), while the productivity tripled. Feeding or delivering calves is still part of ranchers’ days, but activities like racking and analyzing genetic traits of livestock and estimating crop yields are a big part of managing and sustaining the ranch operations. In addition, the business and administration activity like bookkeeping, logistics, market pricing, employee supervision became part of the job due to the increase in average farm size from 200 to 450 acres. Another exampleistheeffectoftheautomatedtellermachine(ATM)onbanktellers, whosenumbergrewfromabout a quarter of a million to a half a million in the 45 years since the introduction of ATMs, see Figure 2 (Bessen 2016). ATM allowed banks to operate branch offices at lower cost, which prompted them to open many 1Despite the settling, differences in the number of hours worked between the low and the high skilled widened in the last fifty years. Men without a high school degree experienced an average reduction of eight working hours a week, while college graduates faced an increase of six hours a week. Similarly, female graduates work 11 hours a week more than those who did not complete high school (Dolton 2017). Overall, American full-time employees work on average 41.5 hours per week, and about 11.1% of employees work over 50 hours per week, which is much higher than countries with a comparable level of productivity like Switzerland, where 0.4% of employees work over 50 hours per week (Feenstra, Inklaar, and Timmer 2015) and part time work is commonplace...
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A Longevity Agenda
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A Longevity Agenda for Singapore
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Over the last 60 years, life expectancy in Singapo Over the last 60 years, life expectancy in Singapore has increased by nearly 20 years to reach 85 – one of the highest in the world. That’s an extraordinary achievement that is taken for granted and that too often leads to a conversation about the costs of an ageing society. Those costs and concerns are very real, but a deeper more fundamental set of questions need to be answered.
If we are living this much longer, then how do we – individuals, companies and governments – respond to make the most of this extra time? How do we restructure our lives to make sure that as many people as possible, live as long as possible, in as healthy and fulfilled ways as possible?
This note draws on the findings from a high-level conference, sponsored by Rockefeller Foundation and Prudential Singapore, to map out what a global longevity agenda looks like, and to raise awareness around the world – at a government, corporate and individual level – on how we need to seize the benefits of this wonderful human achievement of longer lives.
It also looks at the measures that Singapore has taken to adjust to longer lives. Reassuringly, Singapore leads the world along many dimensions that have to do with ageing, and also longevity. However, there is much that needs to be done. Framing policies around longevity and ‘all of life’ and not just ageing and ‘end of life’ is needed if Singapore is to collectively maximise the gains available.
A Longevity Agenda For Singapore I 2
Executive Summary
• Singapore is undergoing a rapid demographic transition which will see the average age of its society
increase as the proportion of its older citizens increases.
• An ageing society creates many challenges. However, at the same time, with the number of older
people increasing, Singapore is benefitting from a longevity dividend.
• On average, Singaporeans are living for longer and in better health. In other words, how we are
ageing is changing – it is not just about there being more senior people. Exploiting this opportunity
to seize these positive advantages is the longevity agenda.
• A new-born in Singapore today, faces the prospect of living on average one of the longest lives in
human history, and so needs to prepare for his or her future differently.
• At an individual level, Singaporeans are already behaving differently – in terms of marriage, families,
work and education. Many are acting as social pioneers as they try to create a new map of life.
• To support individuals as they adapt to longer lives, Singapore needs to create a new map of life
that enables as many people as possible to live as long as possible and as healthily and as fulfilled as
possible.
• Achieving this will also ensure that not only the individual, but also the economy will benefit.
• Singapore is at the international frontier of best practice in terms of adjusting to an ageing society. It
also leads the way with many longevity measures.
• Further entrenching social change and experimentation, and creating a positive narrative around
longer, healthier lives; in particular, extending policies away from a sole focus on the old and towards the whole course of life are some key priorities ahead of us. ...
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A Letter From Santa Claus
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This is the new version of Christmas data
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“A Letter From Santa Claus” is a charming and imag “A Letter From Santa Claus” is a charming and imaginative letter written by Mark Twain to his young daughter, Susy Clemens, pretending to be Santa Claus. In the letter, Santa explains that he has received and read all the letters written by Susy and her little sister about what they want for Christmas. He assures her that he delivered the gifts she asked for personally when the girls were asleep and even kissed them both.
Santa then gives Susy detailed, playful instructions for speaking with him through the house’s speaking tube. He tells her that he will stop by the kitchen door around nine in the morning to confirm a confusing detail from her mother’s letter—whether Susy ordered “a trunk full of doll’s clothes.”
Santa says:
George the servant must answer the door blindfolded
No one must speak or he will “die someday” (said humorously, in Santa’s dramatic style)
Susy must listen at the speaking tube
When Santa whistles, she must say “Welcome, Santa Claus!”
He then promises to fly back to the moon to fetch the trunk and reurn down the hall chimney so he can deliver it properly. He gives more instructions: if snow falls in the hall or if his boot leaves a stain, they must leave it as a reminder for Susy to always be a good little girl.
The letter ends with Santa affectionately signing himself as
“Your loving Santa Claus, whom people sometimes call ‘The Man in the Moon.’”
The piece is warm, magical, and filled with Mark Twain’s gentle humor. It captures the innocence of childhood and the loving playfulness of a father writing to his child during Christmas....
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A Kidnapped Santa Claus
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anta Claus lives happily in the Laughing Valley, w anta Claus lives happily in the Laughing Valley, where he makes toys with the help of ryls, knooks, pixies, and fairies. Everything in the valley is cheerful, and Santa spends his life bringing joy to children. But in the mountain beside the valley live the Daemons of Selfishness, Envy, Hatred, and Malice, who hate Santa because he makes children happy and therefore keeps them away from their evil caves.
The Daemons try to tempt Santa with selfishness, envy, and hatred, but he refuses every attempt. When they cannot change his heart, they decide to stop him by force. On Christmas Eve, when Santa rides out to deliver toys, they throw a rope around him, pull him from his sleigh, and lock him in a secret cave inside the mountain.
Santa’s helpers—Nuter the Ryl, Peter the Knook, Kilter the Pixie, and Wisk the Fairy—realize Santa is missing. Instead of turning back, they decide to deliver the toys themselves so that children will not wake up disappointed. They make a few funny mistakes, but they finish the job before morning.
Afterward, Wisk flies to the Fairy Queen and learns that the Daemons kidnapped Santa. She promises help, and the helpers prepare an enormous magical army of fairies, knooks, pixies, ryls, gnomes, and nymphs to rescue Santa.
Meanwhile, Santa sits imprisoned. The Daemons mock him, but he stays calm. At last, the Daemon of Repentance, who regrets helping with the capture, frees Santa and leads him through a tunnel to safety. Santa walks out into the bright morning just as the magical army arrives to rescue him.
When they see Santa safe, the army rejoices. Santa thanks them and tells them not to fight the Daemons, since evil will always exist in the world but kindness is stronger. He returns home, hears how his helpers saved Christmas, and sends the missing gifts to the children who received the wrong ones.
The Daemons, defeated and embarrassed when no children fell into their caves that day, realize they can never overcome Santa while he has so many good friends. They never try to stop him again....
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ufsdweho-6152
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A Christmas carol
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This is the new version of Christmas
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MARLEY'S GHOST
THE FIRST OF THE
THREE SPIRI MARLEY'S GHOST
THE FIRST OF THE
THREE SPIRITS
THE SECOND OF THE
THREE SPIRITS
THE LAST OF THE SPIRITS
THE END OF IT
LIST OF ILLUSTRATIONS
IN COLOUR
IN BLACK AND WHITE
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{"message": "Training failed: You can& {"message": "Training failed: You can't train a model that has been loaded in 8-bit or 4-bit precision on a different device than the one you're training on. Make sure you loaded the model on the correct device using for example `device_map={'':torch.cuda.current_device()}` or `device_map={'':torch.xpu.current_device()}`"}...
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A Christmas Tree Charles
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Story of Christmas tree
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The Gift of the Magi
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“A Christmas Tree”1850 is a nostalgic piece in wh “A Christmas Tree”1850 is a nostalgic piece in which the narrator looks at a beautifully decorated Christmas tree and is carried back into the memories of his childhood. As he studies each ornament, candle, toy, or decoration, different memories come alive.
At the top of the tree he sees toys from his early years—dolls, little boxes, toy soldiers, dancing figures, and magical objects. Each one reminds him of childhood fears, joys, surprises, and the excitement of Christmas morning. As he looks further down the tree, the memories grow older: picture books, fairytales, and adventure stories he loved, including Jack and the Beanstalk, Little Red Riding Hood, the Arabian Nights, and Noah’s Ark. These stories filled his imagination and made his childhood bright and full of wonder.
Deeper on the branches, Dickens recalls the ghost stories that were part of old Christmas traditions, haunted houses, mysterious visitors, strange dreams, and eerie figures. These memories show how Christmas in earlier times mixed joy with mystery and imagination.
Finally, on the lowest and most mature branches, the narrator remembers how Christmas felt as he grew older: school days ending, returning home for the holiday, going to the theater, listening to the village waits, and thinking of the story of Christ’s birth. The tree becomes a symbol of life itself. from childhood at the top to adulthood at the bottom.
The piece ends with the Christmas tree sinking away, and Dickens reminds the reader that Christmas is celebrated in the spirit of love, kindness, and remembrance....
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A Christmas Dream,
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This is the new version of Christmas data
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“A Christmas Dream, and How It Came to Be True”:
“A Christmas Dream, and How It Came to Be True”:
The story is about a girl named Effie who is disappointed with her Christmas gifts because she already has many toys. That night, she dreams of visiting a poor family who has nothing for Christmas. In the dream, she gives them her own toys and clothes, and she sees how happy it makes them. When she wakes up, she understands the true meaning of Christmas—kindness and giving. She decides to make her dream come true by sharing her gifts with a real needy family....
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{"message": "Training failed: You can& {"message": "Training failed: You can't train a model that has been loaded in 8-bit or 4-bit precision on a different device than the one you're training on. Make sure you loaded the model on the correct device using for example `device_map={'':torch.cuda.current_device()}` or `device_map={'':torch.xpu.current_device()}`"}...
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A Child Christmas in wale
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This the new version of Christmas data
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A Child’s Christmas in Wales is a nostalgic story A Child’s Christmas in Wales is a nostalgic story in which Dylan Thomas remembers Christmas days from his childhood. He describes snowy streets, fun with friends, mischievous adventures, family gatherings, and the warmth of home. The story is told like a collection of memories sweet, funny, and sometimes exaggerated—showing how magical Christmas felt to a child....
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our Epidemic of Loneline
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our Epidemic of Loneliness and Isolation
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“Our Epidemic of Loneliness and Isolation: The U.S “Our Epidemic of Loneliness and Isolation: The U.S. Surgeon General’s Advisory on the Healing Effects of Social Connection and Community” (2023)
Author: Dr. Vivek H. Murthy, U.S. Surgeon General
surgeon-general-social-connecti…
This document is an official U.S. Surgeon General’s Advisory that warns the nation about a growing public health crisis—the epidemic of loneliness, isolation, and declining social connection. It explains that nearly half of Americans regularly feel lonely, and social connection has sharply decreased over the last several decades due to changes in family structure, technology use, community involvement, and societal norms.
The advisory shows that social disconnection is as harmful as smoking 15 cigarettes a day and dramatically increases the risk of heart disease, stroke, dementia, diabetes, depression, anxiety, self-harm, and premature death. It presents decades of scientific evidence demonstrating that strong social relationships, supportive communities, and positive social environments improve physical health, mental well-being, cognitive function, educational outcomes, workplace success, and overall quality of life.
The report explains why humans are biologically wired for connection and describes how loneliness negatively impacts the brain, stress hormones, inflammation, immunity, and behavior. It also highlights how social connection supports meaning, resilience, purpose, and healthier lifestyle choices.
On a community level, the advisory shows that connected communities are safer, more resilient, more prosperous, and more civically engaged. It warns that declining trust, weaker community bonds, and rising polarization undermine national health and social stability.
To address the crisis, the advisory proposes a National Strategy with Six Pillars, calling on governments, schools, workplaces, technology companies, healthcare systems, media, and individuals to strengthen social infrastructure, reform digital environments, promote pro-connection policies, and rebuild a culture of empathy, belonging, and community.
Overall, the document is a comprehensive, research-based call to action emphasizing that social connection is a fundamental human need essential for individual and societal health, and rebuilding it is critical for America’s future...
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longevity guide
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The longevity
guide
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“The Longevity Guide” is an accessible, research-b “The Longevity Guide” is an accessible, research-based magazine-style overview of the science, psychology, and lifestyle practices that contribute to living a longer, healthier, and happier life. Produced by USC Dornsife scholars, it combines behavioral science, neuroscience, nutrition, gerontology, anthropology, psychology, and global well-being traditions to present a holistic picture of longevity. The guide emphasizes that longevity is not simply about adding years to life; it is about adding quality, vitality, and connection to every stage of life.
The Longevity Guide
Key Themes and Insights
1. The Psychology of Healthy Habits
The guide opens by explaining why many people struggle to maintain healthy routines. According to identity-based motivation research, if a health behavior feels difficult, we may believe “it’s not for us,” which leads to avoidance.
Instead, reframing challenge as part of growth—“no pain, no gain”—helps people sustain behaviors that support long-term health. This mindset increases self-efficacy, self-esteem, and resilience.
The Longevity Guide
This principle applies across the life span:
Adolescents who internalize a growth mindset show better academic engagement and fewer depressive symptoms.
Adults who see difficulty as an opportunity—not an obstacle—tend to have healthier habits and stronger well-being.
2. Gut–Brain Connection and Diet for Longevity
The guide highlights the gut as our “second mind,” explaining the deep biological communication between gut microbes and the brain via the vagus nerve. Diet strongly influences memory, stress, and mood.
Research shows:
Sugary or artificially sweetened beverages in adolescence impair memory later in life.
Diets high in whole grains, low in saturated fat, and low in ultra-processed foods support brain function.
The Longevity Guide
Simple actions such as replacing soda with water can produce measurable long-term benefits.
3. Global Well-Being Practices That Boost Longevity
The guide presents five culturally rooted self-care traditions, each supported by scientific evidence:
Shinrin-yoku (Japanese forest bathing): reduces stress, lowers blood pressure, boosts immunity.
Finnish/Swedish saunas: support cardiovascular health, reduce stroke and dementia risk, and improve recovery.
Insect-based nutrition: nutrient-dense, sustainable, and consumed globally.
Cold-water wild swimming: improves mood, cardiovascular health, and immune strength.
Vorfreude (German concept of anticipatory joy): planning small pleasurable moments reduces stress and enhances well-being.
The Longevity Guide
4. Fasting, Spiritual Traditions, and Scientific Longevity
The guide bridges modern research with ancient religious practices.
Fasting—found in Buddhism, Christianity, Islam, and other traditions—aligns strongly with findings from gerontology.
Research from Valter Longo shows that the fasting-mimicking diet (FMD):
reduces biological age
lowers disease-related biomarkers
may reverse late-stage type 2 diabetes
may improve survival in certain cancer patients
This positions fasting as a powerful, evidence-based tool for longevity.
The Longevity Guide
5. Science-Based Health Hacks
The guide evaluates popular health trends:
Morning sunlight improves sleep cycles.
Adding a little salt to water can help hydration—but too much increases risk.
Gratitude journaling improves sleep, lowers inflammation, and increases activity.
10,000 steps is arbitrary—any increase in walking improves health.
Standing desks help with blood sugar but are not a cure-all; alternating positions works best.
Raw milk is NOT healthier—pasteurized milk is safer with no nutrient loss.
The Longevity Guide
6. You're Not Past Your Prime: Life Peaks After 40
The guide challenges myths about aging, showing many abilities peak later in life:
Ultramarathon performance peaks between ages 40–49.
Cognitive skills have multiple late-life peaks:
arithmetic: ~50
vocabulary: late 60s–70s
chess mastery: ~40
Nobel Prize achievements: early 60s
Happiness increases after midlife and continues rising into older age.
Agreeableness increases with age, improving social relationships.
The Longevity Guide
7. Loneliness: A Modern Public Health Crisis
The guide describes loneliness as an epidemic with profound consequences:
Linked to increased risk of stroke, diabetes, dementia, cardiovascular disease, and early death.
Genetic factors play a role, but lifestyle choices can reduce 50–60% of the risk.
Building “belonging maps” and cultivating small daily interactions help form meaningful social ties.
As the guide emphasizes:
“Become someone who creates belonging wherever you go.”
The Longevity Guide
8. Music as Medicine
Music strengthens well-being across the life span:
>Children benefit from improved emotional regulation, empathy, and academic performance
>Older adults gain reductions in loneliness, anxiety, and memory challenges.
>Choir singing enhances vitality and social connection.
Nostalgic music helps those with memory impairment reconnect with personal identity.
>The Longevity Guide
>The message: Everyone can sing—and it’s never too late to start.
>Conclusion
“The Longevity Guide” is a deeply interdisciplinary and inspiring exploration of how to live >longer and better. Through psychology, nutrition, neuroscience, cultural practices, fasting >science, social connection research, and the healing power of music, the guide presents >longevity as a whole-person journey.
Its core message is clear:
Longevity is not a secret—it’s a combination of daily habits, supportive communities, resilient mindsets, and lifelong engagement with body, mind, and meaning....
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lxwwrqjd-9752
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longevity and public
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longevity, working lives
and public finances
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This paper (ETLA Working Papers No. 24, 2014) anal This paper (ETLA Working Papers No. 24, 2014) analyses how increasing longevity affects public finances in Finland, focusing on the interaction between longer lifetimes, working careers, and health- and long-term-care expenditure. Written by Jukka Lassila and Tarmo Valkonen, it combines a review of economic research with simulations using a numerical overlapping-generations (OLG) model calibrated to Finnish demographics and economic structures.
The authors examine three key channels:
Longevity & demographics – Longer life expectancy increases the share of the elderly population and particularly the number of people aged 80+, intensifying long-term care demand. Stochastic mortality projections demonstrate wide uncertainty in future longevity trends.
Longevity & working lives – Evidence suggests that healthier, longer lives could support longer work careers, but this will not occur automatically. Without policy reforms, working lives extend only modestly. Linking retirement age to life expectancy, tightening disability pathways, and reforming pension eligibility can significantly lengthen careers.
Longevity & health/care expenditure – The paper highlights that a substantial portion of healthcare and long-term care costs occur near death rather than being linearly age-related. This reduces the inevitability of cost increases from ageing alone: proximity-to-death modelling shows lower expenditure pressure compared with naïve, age-only models.
Using 500 stochastic population scenarios, the authors simulate long-term fiscal sustainability under varying assumptions about longevity, retirement behaviour, and healthcare cost dynamics. Key findings include:
If working lives do not lengthen, rising longevity substantially worsens public finances.
Under current rules, improvements in health and moderate policy support produce some automatic correction.
Linking retirement age to life expectancy largely neutralizes the fiscal impact of longer lifetimes.
Modelling care costs with proximity-to-death dramatically improves fiscal forecasts compared to simple age-related projections.
Conclusion
Longer lifetimes need not undermine fiscal sustainability—if policies ensure that healthier, longer lives translate into longer working careers and if health-care systems account for the true drivers of costs. With appropriate reforms, generations that live longer can also finance the additional costs generated by their longevity....
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a320bd65-469e-45f5-a98c-4231785f82ad
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vodymxlg-2995
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xevyo
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What Happen all live 100
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What Happens When We All Live to 100?
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What Happens When We All Live to 100?” by Gregg Ea What Happens When We All Live to 100?” by Gregg Easterbrook is an in-depth exploration of how rising life expectancy will transform science, society, economics, politics, and everyday life. The article explains that life expectancy has increased steadily for almost 200 years—about three months every year—and may reach 100 years by the end of this century. This dramatic shift will reshape everything from health care to retirement, family structures, and government systems.
Easterbrook discusses cutting-edge longevity research at places like the Buck Institute, Mayo Clinic, and universities studying how to slow aging, extend “healthspan,” and possibly reverse age-related decline. Scientists have lengthened the lives of worms and mice, identified longevity genes (such as daf-16/foxo3), tested drugs like rapamycin, and explored theories involving caloric restriction, cellular senescence, stem-cell rejuvenation, and youth-blood factors. Much of this research aims not just to add years but to preserve quality of life, preventing diseases like heart disease, cancer, Alzheimer’s, and stroke.
The article also presents two major schools of thought:
(1) Life expectancy will keep rising smoothly (“the escalator”), or
(2) It will hit a biological and social limit.
Experts debate whether future gains will slow down or accelerate due to new anti-aging breakthroughs.
Beyond biology, the article examines massive societal consequences of a population where large numbers routinely live past 90 or 100. These include:
increased strain on Social Security, pensions, and Medicare
a growing gap between educated and less-educated groups in longevity
more years of old-age disability unless healthspan improves
caregiver shortages
political dominance by older voters
possible rise in national debt
multigenerational families depending heavily on one young adult
Japan as an example of an aging society with stagnation and high public debt
The article warns that without healthier aging, longer life could create financial crisis and social imbalance. However, if science successfully extends healthy, active years, society may benefit from:
older adults working longer
less crime and less warfare (younger people start more conflicts)
more intergenerational knowledge
calmer, wiser political culture
reduced materialism
stronger emotional well-being among the elderly
The author concludes that a world where most people live to 100 will be fundamentally different: older, quieter, more stable, and possibly more peaceful. But it also requires urgent changes in healthcare, retirement systems, and public policy. Ultimately, the article argues that humanity is entering an age where delaying aging—and reshaping society around longer lives—is becoming not just possible, but necessary....
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Variation in fitness of
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Variation in fitness of the longhorned beetle, De
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This study examines how the fitness of the longhor This study examines how the fitness of the longhorned beetle Dectes texanus—a major pest of soybean crops—varies across different soybean populations and environments. The research provides a detailed analysis of how factors such as geographic origin, host plant quality, and genetic variation influence beetle survival, development, reproduction, and body size.
Purpose of the Study
The goal is to understand why D. texanus shows substantial differences in life-history traits when feeding on different soybean varieties and when collected from different regions. The authors aim to identify:
how host plant quality affects beetle development,
whether beetle populations show local adaptation to their regional soybean hosts, and
how these differences influence pest severity in agricultural systems.
Key Findings
1. Fitness varies significantly across soybean hosts
Larvae reared on different soybean cultivars showed major differences in:
growth rate
survival to adulthood
adult body mass
developmental time
Some soybean varieties supported rapid growth and high survival, while others produced slower development and lower fitness.
2. Geographic origin matters
Beetles collected from different regions (e.g., Kansas, Texas, Oklahoma, Nebraska) showed distinct performance patterns, suggesting:
genetically based population differences, and
possible local adaptation to regional soybean types.
These geographic differences shaped how well beetles performed on specific soybean hosts.
3. Developmental timing is a key determinant of fitness
Developmental duration strongly influenced adult body size and reproductive potential:
Faster development produced smaller adults with potentially reduced fecundity.
Longer development produced larger adults with greater reproductive output.
Thus, speed–size trade-offs were central to fitness variation.
4. Body size correlates with reproductive capacity
Larger adults produced by favorable host plants—tend to have:
higher egg production in females
stronger survival rates
greater overall fitness
This links host-driven growth differences directly to pest severity in the field.
5. Host plant defenses influence beetle performance
The study highlights how soybean plants with stronger structural or chemical defenses reduce larval growth, suppress survival, and lead to smaller, less successful adults.
This suggests that breeding soybean varieties with anti-beetle traits can meaningfully reduce pest damage.
Scientific Importance
This research shows that Dectes texanus fitness is shaped by the interaction between:
plant genetics,
insect genetics, and
environmental conditions.
It provides valuable insight for agricultural pest management, emphasizing that controlling this beetle requires understanding not just soybean traits but also beetle population biology and regional adaptation.
Conclusion
“Variation in Fitness of the Longhorned Beetle, Dectes texanus, in Soybean” demonstrates that the beetle’s success as a pest is not uniform. Instead, it varies widely depending on soybean variety, beetle population origin, and local environmental conditions. These findings help inform more targeted and effective strategies for soybean crop protection....
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Unlocking the Secrets of
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Unlocking the Secrets of Longevity Recent Finding
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“Unlocking the Secrets of Longevity: Recent Findin “Unlocking the Secrets of Longevity: Recent Findings in Health Research” is a contemporary scientific perspective summarizing the newest discoveries in the biology of aging and the interventions that can extend human lifespan and healthspan. It provides a clear, accessible overview of how genetics, lifestyle, microbiome science, cellular aging, metabolism, and cutting-edge technologies interact to shape longevity.
unlocking-the-secrets-of-longev…
The article emphasizes that longevity is not determined by a single factor but by a complex web of biological, behavioral, and environmental influences. It highlights major scientific breakthroughs that are redefining our understanding of aging and pointing toward future therapies.
Core Themes & Scientific Findings
1. Longevity Genes and the Biology of Aging
The article explains that genetics plays a key role in determining lifespan.
Recent research has identified FOXO3 as one of the strongest genetic markers of exceptional longevity, frequently found in centenarians. FOXO3 regulates:
stress resistance
DNA repair
cellular survival pathways
Additionally, studies on telomeres—the protective caps on chromosomes—show that maintaining telomere length may slow cellular aging and extend lifespan.
unlocking-the-secrets-of-longev…
2. Lifestyle Factors: Diet, Exercise, and Sleep
The article stresses that lifestyle is equally powerful as genetics, explaining:
Diet
Mediterranean-style diets rich in fruits, vegetables, and healthy fats are linked to lower disease risk and longer lifespan.
>Antioxidants reduce oxidative stress, a major driver of aging.
>Exercise
>Physical activity enhances cardiovascular health, strengthens muscle, and slows cellular aging itself.
Exercise may positively influence aging-related gene expression.
Sleep
Adequate sleep supports repair and regeneration; sleep deprivation accelerates age-related decline and disease risk.
Recent work has uncovered molecular links between sleep quality and aging rate.
unlocking-the-secrets-of-longev…
3. The Microbiome: A New Frontier in Longevity
The article highlights the gut microbiome as a critical regulator of health and aging.
Key points include:
Microbial diversity declines with age.
Imbalances in gut microbes are linked to metabolic, immune, and brain-related aging.
Probiotics, prebiotics, and diet-based microbiome interventions show promise for promoting healthy aging.
The microbiome also influences the gut–brain axis, affecting mood, cognitive function, and neurodegeneration.
unlocking-the-secrets-of-longev…
4. Cellular Senescence and Senolytics
A major aging mechanism the article describes is cellular senescence—the buildup of damaged cells that no longer divide. These “zombie cells” cause inflammation and contribute to:
>cardiovascular disease
>arthritis
>neurodegenerative conditions
Recent findings show that senolytic drugs—therapies that selectively remove senescent cells—can improve healthspan and lifespan in animal models. This is one of the most promising therapeutic frontiers in longevity science.
unlocking-the-secrets-of-longev…
5. Metabolism, Fasting, and Longevity Pathways
The article discusses the deep connection between metabolism and aging:
Caloric restriction and intermittent fasting activate cellular repair pathways.
These strategies improve mitochondrial function and metabolic flexibility.
Sirtuins, a family of proteins involved in stress response and energy regulation, are linked to increased lifespan across species.
Researchers are exploring sirtuin-activating compounds to mimic the effects of caloric restriction in humans.
unlocking-the-secrets-of-longev…
6. Technological Advances Transforming Longevity Research
The article highlights groundbreaking technologies reshaping the field:
CRISPR gene editing
Allows direct manipulation of aging-related genes
Raises major ethical considerations
Single-cell sequencing
Reveals how individual cells age
Identifies new therapeutic targets
Artificial intelligence (AI)
Analyzes massive aging datasets
Accelerates the discovery of anti-aging drugs and biomarkers
Together, these tools are pushing the boundaries of what is possible in aging research.
unlocking-the-secrets-of-longev…
Conclusion
“Unlocking the Secrets of Longevity” portrays aging research as a rapidly advancing, multidisciplinary field. Longevity is shaped by a rich combination of:
genetic resilience
robust metabolic and cellular repair
a healthy microbiome
senescent cell clearance
nutrient-dense diets
exercise and quality sleep
technological innovation
The article concludes that while challenges and ethical questions remain, the accelerating pace of discovery offers real promise for extending both lifespan and healthspan, enabling future generations to live longer, healthier, more fulfilling lives....
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